青海地区冠心病危险因素与冠状动脉病变的相关分析

Correlation between coronary artery disease risk factors and characteristics of coronary artery lesions in Qinghai

目的分析青海地区冠心病患者的危险因素,探讨危险因素与冠状动脉病变支数及狭窄程度的相关性。方法选择进行冠状动脉造影并连续住院的患者156例,通过冠状动脉造影确定为冠心病者98例(冠心病组),非冠心病者58例为对照组(非冠心病组)。记录纳入研究对象的临床资料,分析性别、年龄、体质量指数(BMI)、家族史、吸烟程度、左心室射血分数(LVEF)、血脂、血压及血糖水平等心血管病危险因素,探讨冠心病危险因素与冠状动脉病变程度及支数的关系。结果两组患者性别、收缩压(SBP)、总胆固醇(TCH)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、吸烟等方面比较差异有统计学意义(P<0.05);年龄、BMI、高密度脂蛋白胆固醇(HDL-C)、舒张压(DBP)、家族史、血肌酐(Cr)、LVEF等方面比较差异无统计学意义(P>0.05)。冠状动脉病变支数与吸烟史、SBP、LDL-C、FBG呈正相关;与年龄、男性、TCH、TG无相关性。冠状动脉狭窄程度与SBP和FBG呈正相关,与年龄、男性、吸烟、TG、TCH和LDL-C无相关性。结论在青海地区,冠心病的危险因素中,吸烟、男性、SBP、FBG与冠心病患者联系更加紧密,共同促进冠心病的发生及发展。

Objective To explore the correlation between cardiovascular risk factors and characteristics of coronary artery lesions,the degree of stenosis in patients with coronary artery disease（CAD）. Methods Totally 156 patients who under went coronary angiography（CAG） in our hospital were divided into CAD group（n= 98） and non-CAD group（n： 58） which the patients with coronary stenosis 〈50% according to the result of CAG. Their clinical data were retrospectively analyzed, including gender, age, body mass index（BMI）, family history, smoking status, left ventricular ejection fraction（LVEF）, blood lipid, blood pressure and blood sugar levels, the correlation between cardiovascular risk factors and coronary artery lesions was analyzed. Results There was significant difference of gender, systolic blood pressure （SBP）, total cholesterol （TCH）, three acyl glycerin （TG） ,low density lipoprotein cholesterol （LDL-C）,fasting blood glucose （FBG）, smoking between the two groups（P〈0.05）, but no signific.ant difference was found at the level of ages,BMI, high-density lipoprotein cholesterol （HDL-C） ,diastolic blood pressure （DBP）, family history, serum creatinine （Cr）, LVEF between the two groups（P〈0.05）. The number of coronary artery lesion branch were increased with these risk factors ineresed, such as smoking, SBP, LDL-C, FBG, no significant difference with age, male, TCH, TG. The degree of stenosis were increased with SBP,FBG,no significant difference with age,male,smoking,TCH,TG and LDL-C. Conclusion The smoking,males,FBP and SBP are the prominent risk factors of CAD in Qinghai area, prosmote the occurrence and development of CAD together.