新孢子虫抗原及疫苗研究进展

Progress on Antigens and Vaccines of Neospora

新孢子虫病是由犬新孢子虫(Neospora caninum)寄生于牛、羊和犬等多种动物细胞内引起的一种原虫病。新孢子虫寄生于宿主体内可导致孕畜流产或产死胎,以及新生幼畜运动神经障碍和神经系统疾病,给畜牧业造成了很大的经济损失。近年来对新孢子虫抗原蛋白在虫体免疫中的作用研究成为新孢子虫病免疫学研究的热点,新孢子虫抗原蛋白将在新孢子虫疫苗研制中发挥作用。目前还没有预防新孢子虫疫苗投入市场的报道。论文对新孢子虫的抗原蛋白及其疫苗的研究进展进行概述,为疫苗的研制及相应产品的研发提供参考。

Neosporosis is a protozoal disease caused Neospora caninumin cattle,sheep,dogs and other animals.Neospora caninum parasitized in the hosts can lead to abortion or stillborn of pregnant animals,neonatal motor nerve disorders and nervous system diseases and bring great economic losses to livestock.In recent years,the effectiveness of Neospora antigen protein in the parasite immunity research becomes a focus of the study in immune neosporosis.Neospora caninumantigen proteins play an important role in Neospora caninumvaccine of the study.Currently,there is no report about preventive Neosporavaccine in the market.The research progresses on the antigen proteins and vaccines of Neospora caninum were reviewed in the paper and provided the theoretical basis for the development of vaccine and corresponding products in the future.