肺舒配方颗粒治疗慢性阻塞性肺疾病临床研究

Clinical Study of Lung Shu Formula Granule in the Treatment of Chronic Obstructive Pulmonary Disease

目的:观察肺舒配方颗粒治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者的临床疗效及其对COPD患者免疫功能的影响。方法:60例COPD缓解期患者,采用随机数字表法分为观察组30例和对照组30例。两组患者均给予常规西医治疗,对照组口服金水宝胶囊,观察组在对照组基础上加服肺舒配方颗粒。比较两组患者的临床疗效、免疫功能、肺功能、中医证候积分。结果:治疗后,两组患者白介素-6(interleukin-6,IL-6)、IL-8、IL-10、IL-17、肿瘤坏死因子(tumor necrosis factor,TNF-α)、T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)、第1秒用力肺活量占预计值百分比(forced expiratory volume in first second,FEV1)%、FEV1/最大肺活量(forced vital eapacity,FVC)均较治疗前显著好转(P<0.05),观察组较对照组显著好转(P<0.05)。治疗后的中医证候积分观察组为(4.2±1.8)分、对照组为(5.4±1.9)分,均较治疗前显著降低(P<0.05),治疗后观察组中医证候积分低于对照组(P<0.05)。治疗后观察组的临床疗效显著优于对照组(P<0.05)。结论:肺舒配方颗粒治疗COPD患者临床疗效显著,能显著提高患者免疫功能和肺功能。

Objective： To observe the clinical effect of Lung Shu Formula Granule adjuvant treatment of chronic obstructive pulmonary disease patients and its influence on the immune function of patients with COPD. Methods ： 60 patients with COPD were randomly divid- ed into the traditional Chinese medicine group and the control group, each of 30 cases. The two groups were given conventional western medicine treatment, the Chinese medicine group was given Lung Shu Formula Granule, and the control group was given Jinshuibao. The clinical curative effect ,immune function,lung function, syndrome integral of the two groups were compared. Results ： After treatment, the patients in the two groups of interleukin-6 （IL-6）, IL-8, IL-10, IL-17, tumor necrosis factor （TNF alpha）, T lymphocyte subsets （ CD3^＋、CD4^＋、CD8^＋、CD4＋/CD8^＋ ）, forced expiratory volume in the first second （ FEV1% ）, FEV1% ! forced vital eapacity （ FVC ） were compared with those before treatment significantly improved （ P 〈 0.05 ）, TCM group had a significantly better than the control group（P 〈0.05）. After treatment,TCM syndrome integral in the traditional Chinese medicine was （4.2 ± 1.8 ） points and the treat- ment group was （5.4 ± 1.9） points both were significantly lower than before treatment （ P 〈 0.05 ）, the traditional Chinese medicine group was lower than the control group （P 〈 0.05）. After treatment, the clinical efficacy of the traditional Chinese medicine group was significantly better than that of the control group （ P 〈 0.05 ）. Conclusion ： The clinical efficacy of Lung Shu Formula Granule in the treatment of patients with chronic obstructive pulmonary disease is significant, which can significantly improve the immune function and pulmonary function of patients with chronic obstructive pulmonary disease.