补肾健脾活血法治疗糖尿病肾病临床研究

Clinical Study on the Treatment of Diabetic Nephropathy with the Method of Invigorating Kidney,Strengthening Spleen and Promoting Blood Circulation

目的:观察补肾健脾活血法治疗糖尿病肾病的临床疗效。方法:采取随机数字表将70例早期糖尿病肾病患者随机分为观察组(35例)和对照组(35例)。对照组给予常规治疗;观察组在对照组治疗基础上给予补肾健脾活血中药口服,疗程均为4周。分别测定观察组和对照组治疗前后24小时尿蛋白定量、尿白蛋白排泄率(urinary albumin excretion rate,UAER)、血肌酐(serum creatinine,Scr)、空腹血糖、血浆白蛋白、胆固醇。结果:对照组和观察组24小时尿蛋白定量、UAER、Scr、空腹血糖、血浆白蛋白、血胆固醇指标均有明显改善,观察组24小时尿蛋白定量、UAER、Scr、血浆白蛋白等指标改善与对照组比较,差异有统计学意义(P<0.05)。结论:补肾健脾活血法治疗早期糖尿病肾病疗效显著,优于常规单用西药治疗方法。

Objective： To observe the clinical effect of the treatment of diabetic nephropathy by the method of invigorating kidney, strengthening spleen and promoting blood circulation. Methods： 70 cases of early diabetic nephropathy patients were randomly divided into the observation group （35 cases） and the control group （35 cases）. The control group was given conventional treatment, and the observation group was treated with the traditional Chinese medicine invigorating kidney, strengthening spleen and promoting blood circu- lation at the same time, and the course of treatment was 4 weeks. 24-hour urinary protein quantity, urinary albumin excretion rate （UAER）, serum creatinine （Scr）, fasting blood glucose, plasma albumin, cholesterol were measured respectively in the two groups. Re- sults： 24 hours urinary protein quantity, UAER, Scr, fasting blood glucose, plasma albumin, blood cholesterol index were significantly improved in the control group and the observation group. 24 hours urinary protein quantity, UAER, Scr, plasma albumin and other indi- cators in the observation group improved significantly compared with the control group （ P 〈 0.05）. Conclusion ： Early diabetic nephrop- athy with the method of invigorating kidney, strengthening spleen and promoting blood circulation is better than that of the conventional treatment of western medicine.