中西医结合治疗未破裂卵泡黄素化综合征临床研究

Clinical Study on Treatment of Luteinized Unruptured Follicle Syndrome with Combination of TCM and Western Medicine

目的:观察人绒毛膜促性腺激素(human chorionic gonadortropin,HCG)合补肾利湿活血汤加针刺法治疗未破裂卵泡黄素化综合征(luteinized unruptured follicle syndrome,LUFS)的临床疗效。方法:将94例LUFS患者随机分为3组,对照组(A组)肌肉注射HCG,对照组(B组)采用中药联合肌肉注射HCG,治疗组(C组)用HCG合中药内服加针刺治疗,3组均治疗3个月经周期。结果:排卵率C组69.23%、B组51.11%,A组35.56%,3组比较差异有统计学意义(P<0.05)。妊娠率C组58.06%、B组30.00%,A组16.13%,3组比较差异有统计学意义(P<0.05)。结论:HCG合补肾利湿活血汤加针刺能提高排卵率、妊娠率,改善卵巢血流及血雌二醇、促黄体生成素水平,作用机理可能与调节卵巢血流及改善内分泌有关。

Objective： To test for the clinical curative effects of HCG and acupuncture combined with kidney-reinforcing and blood-activ- iting and dampness-eliminating Tang therapy treating patientis with luteinized unruptured follicle syndrome （LUFS）. Methods： 94 cases of LUFS were randomly divided into three groups. The treatment group was given acupuncture and HCG combined with traditional Chi- nese medicine therapy and the control group A just was given intramuscular injection HCG and the control group B was given HCG com- bined with traditional Chinese medicine therapy, each of which lasted 3 months at most. Results ： The ovulation rate and pregnancy rate were 69.23% ,58.06% in C group respectively, vs 35.56% , 16.13% in A group and 51.11% ,30.00% in B group（P 〈 0.05 ）. Con- clusion： HCG and acupuncture combined with kidney-reinforcing and blood-activiting and dampness-eliminating Tang therapy can higb- er ovulation and pregnancy rates, improve ovarian blood flow and blood estradiol, luteinizing hormone levels, which the mechanism can be related with adjusting the ovarian blood flow and improving the endocrine probably.