针灸联合利培酮治疗脑卒中后幻觉症临床研究

Clinical observation of combined acupuncture and Risperidone in treating post-stroke hallucinosis

目的观察针灸联合利培酮治疗脑卒中后幻觉症的临床效果。方法将98例脑卒中后幻觉症患者随机分为两组,每组49例。对照组口服利培酮片治疗,治疗组给予针灸联合口服利培酮片治疗,疗程3周。结果治疗组总有效率为97.96%,对照组为87.76%;治疗组临床疗效明显优于对照组(P<0.05)。治疗后两组躯体化等生活质量评分较治疗前有所降低(P<0.05,P<0.01),且治疗组低于对照组(P<0.05)。治疗后两组患者认知记忆能力评分均较治疗前显著增加(P<0.05),且治疗组评分高于对照组(P<0.05)。治疗后两组患者血浆5-HT含量明显增加(P<0.05),且治疗组血浆5-HT含量明显高于对照组(P<0.05)。结论针灸联合利培酮片治疗脑卒中后幻觉症能改善患者临床症状、提高生活质量,其机制可能与促进血浆5-HT释放有关。

Objective To observe the clinical efficacy of acupuncture and Risperidone in the treatment of post-stroke hallucinosis. Methods Ninety-eight subjects were randomized into two groups ： control group in which 49 eases were orally given Risperidone, and treatment group in which 49 cases were given acupuncture and oral Risperidone, with a course of three weeks. Results The total effective rate was 97.96% in the treatment group and 87.76% in the control group, with better effects in the treatment group than in the control group（ P 〈0.05 ）. After treatment, the scores of such symptoms of life quality as somatization were reduced in both groups（P 〈0.05, P 〈0.01 ） , with lower scores in the treatment group than in the control group（ P 〈0.05 ）. After treatment, the cognitive and memory scores were obviously increased in both groups（ P 〈0.05 ）, with higher score in the treatment group than in the control group（ P 〈0.05 ）. The contents of plasma 5-HT were significantly increased after treatment in both groups （P 〈 0.05 ）, with higher content in the treatment group than in the control group （P 〈 0.05 ）. Conclusion In the treatment of post-stroke hallucinosis, acupuncture with Risperidone can effectively improve clinical symptoms and life quality possibly by promoting the release of plasma 5-HT.