新诊断2型糖尿病患者胰腺脂肪含量与血脂水平相关性研究

The relationship of pancreatic fat content and lipid levels in individuals with newly diagnosed type 2 diabetes

目的 探讨新诊断2型糖尿病患者的胰腺脂肪含量与血脂水平的相关性.方法 对54例新诊断的2型糖尿病患者和22例无糖尿病志愿者行胰腺氢质子磁共振波谱成像技术扫描,测量并计算胰腺脂肪含量.分析胰腺脂肪含量与血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇的相关性.结果 新诊断2型糖尿病患者的胰腺脂肪含量为（17.13 ±10.35）％,显著高于对照组（11.62±7.15）％（P=0.025）.相关性分析表明,新诊断2型糖尿病患者的胰腺脂肪含量与血清总胆固醇（r=-0.361,P=0.007）、低密度脂蛋白胆固醇（r=-0.346,P=0.010）水平呈负相关,而与血清甘油三酯水平及高密度脂蛋白胆固醇水平无关（P＞0.05）.结论 血清总胆固醇及低密度脂蛋白胆固醇水平升高可能有助于减轻胰腺脂肪沉积的程度.

Objective To investigate association of pancreatic fat content and lipid levels in individuals with newly diagnosed type 2 diabetes.Methods Fifty four subjects with newly diagnosed type 2 diabetes and 22 volunteers without type 2 diabetes were enrolled in this study.Pancreatic fat content was determined with magnetic resonance imaging.Lipid levels were measured.Results The pancreatic fat content in patients with newly diagnosed type 2 diabetes and control subjects was （17.13 ± 10.35） % and （11.62 ±7.15）%, respectively （P =0.025）.Median pancreatic fat content of subjects with newly diagnosed type 2 diabetes correlated negatively with total cholesterol level （r =-0.361, P =0.007） and triglycerides level （r =-0.346, P =0.010）.Conclusions Increased levels of serum total cholesterol and low density lipoprotein cholesterol might relieve the extent of pancreatic fat content.