摘要
目的 研究帕金森病（PD）患者血清胱抑素C（CC）水平的变化,及其与H＆Y评分、PD患病时间之间的关系.方法 收集PD患者（PD组）432例,健康体检者（对照组）513例,根据H＆Y评分将PD组分为3个亚组,分别检测CC浓度及Scr浓度,进行统计学分析.结果 PD组与对照组CC浓度比较差异有统计学意义（P＜0.05）,Scr浓度在两组中差异无统计学意义（P＞0.05）.PD组各亚组中,中期组CC浓度高于早期组及对照组（P＜0.05）,晚期组CC浓度明显高于对照组及其他两个亚组（P＜0.05）,秩相关分析对比CC浓度与PD患病时间呈正相关（r=0.209,P＜0.01）,CC浓度与H＆Y评分呈正相关（r=0.618,P＜0.01）.结论 CC水平与PD有一定相关性,PD患者的CC水平明显增高.在疾病初始阶段升高不明显,也许CC不一定是PD发病的原因,但其水平与H＆Y评分及患病时间呈正相关,CC可能参与疾病进展的过程,高水平的CC可能会加重PD患者病情.
Objective To investigate the levels of cystatin C （CC） with the H＆Y scale and duration of Pakinson＇s disease（PD）patients.Methods The study consists of 432 PD patients and 513 control subjects.PD patients were divided into 3 subgroups according to their H＆Y scale.The levels of CC and Scr were measured.The statistics analysis was used to evaluate their associations.Results In PD and control groups, CC concentrations were significantly different （P 〈 0.05）, and Scr concentrations in two study groups were not significantly different（P 〉 0.05）.PD in each subgroup, CC concentrations in the medium group were significantly higher than the early and control groups, and CC in the late group was significantly higher than the other two subgroups.Rank correlation analysis and comparison of CC concentration and duration and H＆Y score showed that CC concentration was positively correlated with the duration of PD（r =0.209, P 〈0.01）, and that CC concentration and H＆Y score were significantly positively correlated （r =0.618, P 〈0.01）.Conclusions There was a certain correlation between CC levels and PD, and CC levels of PD patients were significantly higher.There was no significant increased CC in the initial stages of the disease, perhaps CC was not necessary cause of the onset of PD.However, the level of CC with H＆Y stage and duration were positively correlated, perhaps CC may be involved in the process of disease progression, because high level of CC may increase PD patient＇s condition.
出处
《中国医师杂志》
CAS
2015年第11期1690-1693,共4页
Journal of Chinese Physician
