抑郁症首次发病未治疗患者脑半球间功能连接的静息态功能磁共振成像研究

Interhemispheric functional connectivity in untreated first-episode major depressive disorder： a resting-state functional magnetic resonance imaging study

目的采用静息态功能磁共振成像（resting-state functional magnetic re, sonance imaging,rs-fMRI）的基于体素镜像同伦连接（voxel-mirrored homotopic connectivity,VMHC）方法研究抑郁症患者双侧半球间的功能连通性。方法选取30例首次发作、既往未服药的抑郁症患者（患者组）和70名健康对照者f对照组）进行rs．fMRI扫描，将基于VMHC的方法应用于数据分析，比较患者组与对照组的全脑VMHC图像，并将差异有统计学意义（校正后P〈0．05）脑区的VMHC值与24项HAMD评分进行相关分析。结果与对照组相比，患者组在双侧小脑后叶（t=-3．74）、梭状回，舌回（t=-3．29）的VMHC值显著减低，未发现这些脑区的VMHC值与24项HAMD评分具有相关性（r=-0．16，P=0．451；r=-0．22，P=0．295）。结论抑郁症患者在静息状态下存在两侧半球间的功能连接异常。

Objective To investigate functional connectivity between the two hemispheres in major depressive disorder using voxel-mirrored homotopic connectivity （VMHC） based on resting-state functional magnetic resonance imaging （rs-fMRI）. Methods Thirty patients with unmedicated major depressive disorder and 70 normal controls underwent the rs-fMRI. The whole brain VMHC was calculated and correlation analysis was performed between the regional VMHC and HAMD scores. Results The major depressive disorder patients showed lower VMHC than normal controls in the cerebellum posterior lobe （t=-3.74）, and fusiform/lingual gyrus （t=-3.29）. There were no significant correlations between the VMHC values in these regions and HAMD scores （r=-0.16, P=0.451;r=-0.22, P=0.295）. Conclusion The functional coordination between homotopic brain regions be impaired in major depressive disorder.