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Receptor-mediated inhibitory mechanisms and the regulation of platelet function

Receptor-mediated inhibitory mechanisms and the regulation of platelet function
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摘要 Platelets are derived from megakaryocytes;they circulate in mammalian blood vessels and play essential roles in hemostasis and thrombosis.When platelets encounter injury,they respond by triggering the formation of a blood clot to prevent blood loss(hemostasis).While this is vital for survival, Platelets are derived from megakaryocytes;they circulate in mammalian blood vessels and play essential roles in hemostasis and thrombosis.When platelets encounter injury,they respond by triggering the formation of a blood clot to prevent blood loss（hemostasis）.While this is vital for survival,
作者 CHENG ZhiPeng LIU JunLing
机构地区 Department of Biochemistry and Molecular Cell Biology Institute of Hematology
出处 《Science China(Life Sciences)》 SCIE CAS CSCD 2015年第12期1299-1301,共3页 中国科学（生命科学英文版）
基金 supported by the National Natural Science Foundation of China(91439115) the National Basic Research Program of China(NO2012CB518000)
关键词 vital triggering Receptor encounter respond aggregation downstream prostaglandin PPAR thrombin 血小板功能 抑制机制 受体介导 血栓形成 巨核细胞 哺乳动物 止血 血管
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献10

  • 1Davi G, Patrono C. Platelet activation and atherothrombosis. N Eng J Med, 2007, 357:2482-2494.
  • 2Offermanns S. Activation of platelet function through G protein-coupled receptors. Circ Res, 2006, 99:1293-1304.
  • 3Moroi AJ, Watson SP. Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors:haemostasis, platelet activation and antithrombotic therapy. Biochem Pharmacol, 2015, 94:186-194.
  • 4Alshahrani MM, Yang E, Yip J, Ghanem SS, Abdallah SL, deAngelis AM, O'Malley CJ, Moheimani F, Najjar SM, Jackson DE. CEACAM2negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2pathways and thrombus growth in vitro and in vivo. Blood, 2014, 124:2431-2441.
  • 5Weng Z, Li D, Zhang L, Chen J, Ruan C, Chen G, Gartner TK, Liu J. PTEN regulates collagen-induced platelet activation. Blood, 2010, 116:2579-2581.
  • 6Fan X, Shi P, Dai J, Lu Y, Chen X, Liu X, Zhang K, Wu X, Sun Y, Wang K, Zhu L, Zhang CC, Zhang J, Chen GQ, Zheng J, Liu J. Paired immunoglobulin-like receptor B regulates platelet activa-tion. Blood, 2014, 124:2421-2430.
  • 7Du X. Self-control of platelets:a new ITIM story. Blood, 2014, 124:2322-2323.
  • 8Spyridon M, Moraes LA, Jones CI, Sage T, Sasikumar P, Bucci G, Gibbins JM. LXR as a novel antithrombotic target. Blood, 2011, 117:5751-5761.
  • 9Leslie CC. Cytosolic phospholipase A2:physiological function and role in disease. J Lipid Res, 2015, 56:1386-1402.
  • 10Yu Y, Ricciotti E, Scalia R, Tang SY, Grant G, Yu Z, Landesberg G, Crichton I, Wu W, Puré E, Funk CD, FitzGerald GA. Vascular COX-2modulates blood pressure and thrombosis in mice. Sci Transl Med, 2012, 4:132ra154.
Science China(Life Sciences)
2015年 第12期

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