淋巴细胞免疫治疗对复发性流产患者免疫调节功能及妊娠结局的影响

Effect of lymphocyte immune therapy on immune regulation function and pregnancy outcomes in patients with recurrent miscarriage

目的研究淋巴细胞免疫治疗对复发性流产患者免疫调节功能及妊娠结局的影响。方法选择2012年4月-2013年4月习惯性流产患者120例为研究对象,采用数字表法随机分为免疫治疗组和对照组,免疫治疗组进行淋巴细胞免疫治疗,对照组仅给予常规保胎治疗。比较2组患者的妊娠结局、免疫细胞以及免疫因子含量。结果妊娠结局:免疫治疗组患者妊娠成功率高于对照组,再次流产率低于对照组,差异有统计学意义(P<0.05);免疫功能:治疗后患者的CD4+T细胞数量以及免疫球蛋白(Ig G、Ig M)、TNF-α、IFN-γ含量低于治疗前,CD8+T细胞的数量以及IL-10、IL-13含量高于治疗前,差异有统计学意义(P<0.05)。结论淋巴细胞免疫治疗有助于改善复发性流产患者的妊娠结局,同时调节免疫功能,增强母体对胎儿的免疫耐受。

Objective To study the effect of lymphocyte immune therapy on immune regulation function and pregnancy out- comes in patients with recurrent miscarriage. Methods 120 patients with recurrent miscarriage in our hospital from April 2012 to April 2013 were selected and divided into immunotherapy group and control group. Immunotherapy group was given immune lymphocyte immunotherapy, and control group was given conventional tokotysis treatment. Then pregnancy outcomes, immune cells and immune factors content of the two groups were compared. Results Pregnancy outcomes was that success pregnancy rate in immunotherapy group was higher than control group, abortion rates were lower than control group, and the differences had statistical significance（P 〈 0.05） ; immune function was that after treatment, the patient＇ s CD4 ＋ T cell count and IgG, IgM, TNF-α, IFN -γcontents were less than those before treatment; CD8 ＋ T cells count and IL- 10, IL- 13 contents were higher than those before treatment, and the differences had statistical significance （P 〈 0.05）. Conclusion Lymphocyte im- mune therapy is helpful to improve the recurrent miscarriage patients＇ pregnancy outcome, while to regulate immune function, and enhance maternal fetal immune tolerance.