阿立哌唑对利培酮所致高催乳素血症的中老年女性精神分裂症患者维持治疗的影响

Effect of aripiprazole on the hyperprolactinmia induced by risperidone in quinquagenarian female schizophrenia patients

目的探讨加用阿立哌唑对利培酮所致高催乳素血症的中老年女性慢性精神分裂症患者的维持期病情稳定性及安全性。方法采用随机数表法将107例长期服用利培酮维持治疗的病情稳定的、有血清催乳素不同程度升高的中老年(年龄≥50岁)、符合《中国精神障碍分类与诊断标准(第3版)》(CCMD-3)精神分裂症诊断标准的女性患者分为研究组(52例)和对照组(55例)。研究组减1mg利培酮的同时加用阿立哌唑5mg/d,对照组维持原有治疗方案不变,总疗程12周,于治疗前和治疗第4、8、12周末检测血清催乳素含量,并采用阳性和阴性症状量表(PANSS)、副反应量表(TESS)评定症状和不良反应。结果研究组治疗第4、8、12周末血清催乳素水平较同期对照组低,差异有统计学意义(P<0.01)。两组治疗前后PANSS及TESS评分差异均无统计学意义(P>0.05)。结论利培酮联合小剂量阿立哌唑可维持中老年女性精神分裂症患者的病情稳定,且有助于降低利培酮所致血清高催乳素水平,药物不良反应未见增多。

Objective To investigate the efficacy and safety of aripiprazole on the hyperprolactinmia induced by risperidone in maintenance period patients with amenorrhea female schizophrenia. Methods 107 maintenance period patients with amenorrhea female and hyperprolactinmia schizophrenia(standard of CCMD - 3)patients who had received risperidone were randomly by random number table assigned to research group(n = 52)and control group(n = 55). And then the research group were administered additional aripi-prazole 5 mg daily when reduce 1mg risperidone and the control group patients were no - changed in the dosage of risperidone for 12 weeks. The plasma prolactin leveI was measured before and after treatment of 4th ,8th ,12th week,and the Positive and Negative Syn-drome Scale(PANSS)and Treatment Emergent Symptom Scale(TESS)were assessed. Results The plasma levels of reseach group at 4th ,8th ,12th were lower than that of the control group. The incidence of side effects and the Positive and Negative Syndrome Scale (PANSS)showed no significant difference between the two groups(P > 0. 05). Conclusion The results indicate that aripiprazole combined with risperidone may be effective and safe for the treatment of maintenance period patients with amenorrhea female and hyper-prolactinmia patients with risperidone induced hyperprolactinemia.