可降解磷酸钙生物陶瓷的制备与性能

The preparation and properties of degradable calcium phosphate bioceramics

通过用磷酸二氢钙与碳酸钙粉体、磷酸氢钙与硫酸钙粉体进行混合烧结制方法制备了一系列磷酸钙生物陶瓷材料,并通过XRD、FI-IR、降解试验、钙磷比分析、SEM观察和细胞毒性实验对改性磷酸钙陶瓷进行了表征。结果表明,在750℃烧结下,磷酸二氢钙与碳酸钙摩尔比为1∶1时生成磷酸三钙,其摩尔比为1∶2与1∶2.3时生成磷酸三钙、羟基磷灰石双相生物陶瓷;磷酸氢钙与硫酸钙摩尔比为1∶0.67与1∶0.5,经烧结后生成焦磷酸钙与硫酸钙双相生物陶瓷。降解试验表明焦磷酸钙与硫酸钙双相生物陶瓷在PBS中浸泡28 d后,其失重率分别为35%和36%,且对浸泡液pH值无显著影响;而得到磷酸三钙陶瓷和磷酸三钙、羟基磷灰石复相陶瓷降解较小,且对pH值有明显影响。细胞毒性实验表明,焦磷酸钙与硫酸钙双相生物陶瓷无细胞毒性。

Using sintering methods on the mixture of the calcium dihydrogen phosphate and calcium carbonate powder,and the calcium hydrogen phosphate and calcium sulfate powder,a series of calcium phosphate bioceramics materials were prepared. The samples were detected by XRD,FI-IR,degradation experiments,calcium and phosphorus ratio analysis,SEM observation and cytotoxicity test. Results showed that under the 750 ℃ sintering,calcium dihydrogen phosphate and calcium carbonate with 1∶ 1 mole ratio generated calcium phosphate. When the molar ratios were 1∶ 2 and 1∶ 2. 3,the calcium phosphate and hydroxyapatite bipolar biological ceramic was generated. Calcium hydrogen phosphate and calcium sulfate with molar ratios of 1∶ 0. 67 and 1 ∶ 0. 5 generated the calcium pyrophosphate and calcium sulfate bipolar biological ceramics. Degradation experiment showed that the weight loss of calcium pyrophosphate and calcium sulfate bipolar biological ceramics were 35% and 36%,respectively,after soaking in PBS for 28 days,and had no significant effect on the p H values of soaking liquid. Also the cytotoxicity test showed that the calcium pyrophosphate and calcium sulfate bipolar biological ceramics was non-toxic to cells.