绝经后2型糖尿病患者跟骨定量超声的测定

Assessment of calcaneus bone strength in postmenopausal women with type 2 diabetes by quantitative ultrasonography

回顾分析47例绝经后2型糖尿病（T2DM）患者跟骨定量超声检测资料。T2DM患者超声传播速率、宽频超声衰减值及刚度系数水平分别为（1015±170）m／s、（84±14）dB／MHz和45±8，显著低于30例正常对照者的（1403±232）m／s、（111±18）dB／MHz和66±12（均P〈0．001）；多元线性回归分析显示，胰岛素抵抗指数是T2DM患者定量超声指标的独立相关因素与独立影响因素。提示T2DM患者跟骨骨强度下降。

The calcaneus bone strength was assessed by quantitative uhrasonography in 47 postmenopausal women with type 2 diabetes mellitus （T2DM group） and 30 healthy postmenopausal women （control group）. Speed of sound （SOS）, broadband ultrasound attenuation （BUA） and stiffness index （SI） in T2DM patients were （ 1 015 ± 170） m/s, （84 ± 14） dB/MHz and 45 ± 8, respectively, which were significantly lower than those of control group （ 1403 ± 232） m/s, （ 111 ± 18 ） dB/MHz and 66 ± 12 （ all P 〈 0. 001 ）. Stepwise muhiple regression analysis showed that homeostasis model assessment of insulin resistance （IR） was independently correlated with the parameters of quantitative uhrasonography in T2DM patients. The results suggest that calcaneus bone strength is reduced in postmenopausal women with T2DM.