摘要
目的:探讨趋化因子受体4(CXCR4)、趋化因子受体7(CXCR7)在膀胱癌中的表达及其意义。方法:分别采用免疫组化和逆转录聚合酶链反应法检测50例膀胱癌及20例癌旁组织中CXCR4和CXCR7的表达情况。应用统计学分析两者的表达与临床分期、病理分级等因素之间的关系,以及两者在膀胱癌中表达的相关性。结果:在膀胱癌组织中CXCR4、CXCR7的表达均明显高于癌旁组织(P<0.05);CXCR4、CXCR7的表达与膀胱癌的临床分期、病理分级相关(P<0.05);在膀胱癌组织中CXCR4与CXCR7的表达呈正相关(r=0.438,P<0.05)。结论:CXCR4、CXCR7与膀胱癌的发生、发展密切相关。
Objective： To explore the expression of CXCR4 and CXCR7 and its significance in bladder cancer.Methods： The expression of CXCR4 and CXCR7 in 50 bladder cancer tissues and 20 normal bladder tissues were examined by immunohistochemical staining and RT-PCR respectively. The relationship beween CXCR4,CXCR7 and tumor clinical stage,pathological grade were analyzed. Results： The expression of CXCR4 and CXCR7 in bladder cancer tissues were significantly higher than those in normal bladder tissues（ P〈0. 05）; The expression of CXCR4 and CXCR7 were related to clinical stage and degree of differentiation（ P〈0. 05）; The expression of CXCR4 and CXCR7 in bladder cancer were positive correlation（ r = 0. 438,P〈0. 05）. Conclusion： CXCR4,CXCR7 are abnormally co-expressed in bladder cancer tissues,suggesting that they are closely related with progression of bladder cancer.
出处
《现代医学》
2015年第10期1219-1222,共4页
Modern Medical Journal
