AP患者hs-CRP与EOS的相关性分析

Association of hs-CRP and EOS in AP Patients

目的探讨急性胰腺炎(AP)患者超敏C反应蛋白(hs-CRP)和嗜酸性粒细胞(EOS)的变化,并分析两者相关性。方法 AP组:南开医院的2013年1月-2015年8月的AP患者346例。对照组:100例同期本院健康体检者。检测hsCRP和EOS含量和百分比,并比较两组各种参数,相关性分析应用Pearson。结果 AP组hs-CRP显著高于对照组,差异有统计学意义(P<0.01),AP组EOS含量和百分比均低于对照组,差异有统计学意义(P<0.05);AP组hs-CRP与EOS含量及百分比呈负相关,差异有统计学意义(r=-0.161,P<0.05;r=-0.285,P<0.01)。结论 AP患者的hs-CRP升高,EOS含量和百分比降低;两者呈负相关;其相关性或能作为AP诊断和疗效观察的一个指标。

Objective To explore the changes of high sensitive C reaction protein（hs-CRP） and eosinophils （EOS） in patients with acute pancreatitis （AP）, and analyze the association of the two. Methods AP group： 346 AP patients who were treated in Nankai hospital from January 2013 to August 2015, the control group： 100 medically healthy individuals who were chosen in the same period of time. hs-CRP and EOS counts and percentages were determined and some parameters were compared between two groups. Associa- tion of the two was evaluated by Pearson correlation. Results Hs-CRP in AP group was significantly higher than that in the control group （P〈0.01）, EOS counts and percentages in AP group were lower than that in the control group （P〈0.05）. There was a significant inverse correlation between both （r=-0.161, P〈0.05; r=- 0.285, P〈0.01 ）. Conclusions AP patients presented increasing hs-CRP and decreasing EOS counts and percentages. Both appeared negative correlation. It was possible that the correlation was used as an index of the diagnosis and treatment of AP.