孟鲁司特联合沙美特罗替卡松对哮喘患者疗效、血清IL-6、IL-8和IL-10水平的影响

Effects of Montelukast Combined with Salmeterol Xinafoate and Fluticasone Propionate on the Efficacy,Serum IL-6,IL-8 and IL-10 Levels in Asthma Patients

目的:探讨孟鲁司特联合沙美特罗替卡松治疗对哮喘患者血清IL-6、IL-8和IL-10水平的影响。方法:80例哮喘患者随机分为对照组(n=42)与观察组(n=38)。对照组仅采用沙美特罗替卡松治疗,观察组在此基础上联合孟鲁司特进行治疗。疗程均为9个月。观察两组临床疗效,比较两组患者治疗前后肺功能指标及血清IL-6、IL-8及IL-10水平变化情况。结果:观察组临床总有效率为92.11%,显著高于对照组73.81%(P<0.05)。观察组患者治疗后肺功能指标(FEV_1、FEV_1,预计值、FEV_1/FVC及PEF)水平均显著高于本组治疗前及对照组治疗后(P<0.05);两组治疗前后血清IL-6、IL-8及IL-10水平差异均有统计学意义(P<0.05),且治疗后两组上述炎症指标水平差异也均有统计学意义(P<0.05)。结论:孟鲁司特联合沙美特罗替卡松可对哮喘患者血清相关炎症因子产生显著性影响应在临床上进行推广及使用。

Objective： To discuss the effect of montelukast combined with salmeterol xinafoate and fluticasone propionate on serum IL-6, IL-8 and IL-10 levels in asthma patients. Methods： Totally 80 patients with asthma were randomly divided into the control group （n = 42） and the observation group （n = 38）. The control group was treated with salmeterol xinafoate and fluticasone, and the observa- tion group was treated with the combination of montelukast and salmeterel xinafoate and ttuticasone. The course of treatment was 9 months. The clinical efficacy and the changes of IL-6, IL-8 and IL-10 in the two groups were compared before and after the treatment. Results： The clinical total effective rate of the observation group was 92.11%, which was significantly higher than that of the control group （73.81%, P 〈0.05）. The correlation indices （ FEV1, FEV1, PEF and FEV1/FVC） of the lung ventilation function in the observation group were significantly higher than those in the control group （ P 〈 0.05 ）. Before and after the treatment, the differences in the levels of serum IL-6, IL-8 and IL-10 were statistically significant （ P 〈 0.05 ）, and the differences between the two groups were also statistically significant （ P 〈 0.05 ）. Conclusion： Mantelukast combined with salmeterol and fluticasane propionate can significantly affect on the inflammatory factors in serum of patients with asthma, which should be used and popularized in clinics.