ABCC2基因单核苷酸多态性对药物临床应用的影响

Effect of Single Nucleotide Polymorphisms in ABCC2 on Clinical Drug Application

目的:综述ABCC2基因单核苷酸多态性对药物临床应用的影响。方法:通过查阅国内外已发表见刊的相关文献,对ABCC2基因单核苷酸突变与药物临床应用的相关性加以归纳总结。结果:ABCC2转运蛋白在许多内源性化合物和外源性化合物的跨膜转运中起到重要作用。大量研究证明了ABCC2的单核苷酸突变可能影响其表达水平或功能活性,进而影响底物药物或有毒物质的吸收、分布和排泄,但这些研究结果多数存在一定的局限性和争议。结论:ABCC2单核苷酸多态性对某些药物的临床应用有一定的影响,对指导临床用药和评估药物疗效有重要的参考价值,但目前并不能作为唯一的指标。

Objective： To summarize the single nucleotide polymorphisms （SNPs） in ABCC2 and the effect on clinical drug application. Methods： According to the related articles published in domestic and abroad, the correlation between the single nucleotide po1ymorphisms in ABCC2 and drug responses was classified and summarized. Results： ABCC2 translocator played an important role in the transmembrane transport of many physiological compounds and exogenous compounds. Numerous studies have demonstrated that the single nuchotide polymorphisms in ABCC2 possibly affected the expression or activity of ABCC2, which leading to the variation in the absorption, distribution and excretion of certain drugs and toxicants. However, the limitation and controversy were still emerged in the results. Conclusion： The influence of ABCC2 single nucleotide polymorphisms on clinical drug application shows significantly referential value for the guidance of medication and the evaluation of efficacy, however, it can not be used as the only indicator yet.