血清胱抑素C和超敏C反应蛋白检测对原发性高血压患者并发心脑血管不良事件的预测价值

Predictive value of detection of serum Cys -C and hs -CRP in cardiovascular adverse events in patients with primary hypertension

目的：探讨血清胱抑素 C（Cys-C）和超敏 C 反应蛋白（hs-CRP）检测对高血压患者心脑血管不良事件的预测价值。方法检测138例高血压患者的 Cys-C 和 hs-CRP 水平，常规治疗，血压控制平稳。2年后根据心脑血管不良事件发生情况分为稳定组（96例）和进展组（42例），另选取同期健康体检者为对照组（42例），复测 Cys-C 和 hs-CRP 水平。回顾性分析两组检测结果和并发症发生情况。结果稳定组和进展组患者初查 Cys-C[（0．87±0．39）mg／L，（1．16±0．47）mg／L]和 hs-CRP[（1．79±0．56）mg／L，（2．26±0．91）mg／L]水平显著高于对照组[（0．59±0．32）mg／L，（0．68±0．37）mg／L]，且进展组高于稳定组，差异均有统计学意义（t ＝2．162、3．904、5．237、6．441，均 P ＜0．01）。复查时，进展组 Cys-C[（1．39±0．41）mg／L]和 hs-CRP[（3．37±0.89）mg／L]水平比稳定组高[（0．92±0．43）mg／L，（1．83±0．62）mg／L]，差异均有统计学意义（t ＝2．958、5.119，均 P ＜0．01）。与初查时相比，稳定组2年后 Cys-C 和 hs-CRP 水平差异无统计学意义（t ＝0．331、0.414，均 P ＞0．05），而进展组复测值有显著增高，差异均有统计学意义（t ＝2．146、3．144，均 P ＜0．01）。结论高血压患者血清 Cys-C 和 hs-CRP 水平与病情进展和预后关系密切，对其监测可提示病情发展方向，有利于指导早期采取更有力的干预措施。

Objective To explore the predictive value of detection of serum Cys -C and hs -CRP in cardio-vascular adverse events of patients with primary hypertension.Methods 138 patients with hypertension were selected and their serum Cys -C and hs -CRP levels were detected.Patients were given conventional treatment and blood pressure was controlled stably.Two years later,patients were divided into stable group（96 cases）and progression group（42 cases）according to the occurrence of cardiovascular adverse events,additionally,42 people received physi-cal examination in corresponding period were selected as control group.The levels of serum Cys -C and hs -CRP were detected again.The detection results and complications were analyzed retrospectively.Results For initial detec-tion,the levels of serum Cys -C[（0.87 ±0.39）mg/L,（1.16 ±0.47）mg/L]and hs -CRP[（1.79 ±0.56）mg/L, （2.26 ±0.91）mg/L]in the stable and progression groups were higher than the control group[（0.59 ±0.32）mg/L, （0.68 ±0.37）mg/L],and those in the progression group were higher than the stable group（t =2.162,3.904, 5.237,6.441,all P〈0.01）.For the reexamination,the levels of serum Cys -C[（1.39 ±0.41）mg/L]and hs -CRP [（3.37 ±0.89）mg/L]in the progression group were higher than the stable group[（0.92 ±0.43）mg/L,（1.83 ± 0.62）mg/L]（t =2.958,5.119,all P〈0.01）.The levels of serum Cys -C and hs -CRP in the stable group after 2 years were similar to those at initial detection（t =0.331,0.414,all P〉0.05）,but the levels in the progression group increased obviously（t =2.146,3.144,all P〈0.01）.Conclusion The levels of serum Cys -C and hs -CRP were closely related to disease progression and prognosis.And the detection of them can predict the progression of disease,conductive to taking intervening measures for the early stage.