干扰素雾化吸入辅助治疗小儿手足口病的疗效观察

Clinical observation of interferon by aerosol inhalation as a part of treatment of hand -foot -and -mouth disease of children

目的：观察干扰素雾化吸入辅助治疗小儿手足口病的临床疗效。方法收集240例手足口病（普通型）患儿的临床资料，将患儿按住院顺序随机分为 A 组（对照组）与 B 组（干扰素治疗组）。比较两组患儿体温复常时间、手足疱疹消退时间、口腔疼痛好转时间、平均住院时间及总有效率。结果干扰素治疗组在口腔疼痛好转时间、手足疱疹消退时间、平均住院时间均优于对照组[（52．8±19．5）h 比（60．5±22．1）h，（54．7±22．5）h 比（72．3±25．4）h，（108．2±36．7）h 比（124．8±42．4）h]（t ＝2．45、2．38、2．16，P ＝0．015、0.018、0．032）；干扰素治疗组总有效率为93．0％，优于对照组的85．3％，差异有统计学意义（χ2＝6．012，P ＝0.012）。结论干扰素雾化吸入辅助治疗小儿手足口病（普通型）能提高治疗有效率，缩短病程，促进症状缓解。

Objective To observe the clinical efficacy of interferon by aerosol inhalation as a part of treat-ment of hand,foot and mouth disease of children.Methods The clinical data of 240 children with hand foot and mouth disease were collected,and they were divided into group A （control group）and group B （interferon treatment group）according to the order of admission.The recovery time on body temperature,rashes on the hands and feet, mouth pain,the average hospitalization time and total efficacy rate were compared.Results Group B was superior to group A in the following aspects,it took shorter time to get recovery of mouth pain,rashes on hands and feet,the aver-age hospitalization time.The recovery time for mouth pain of group A was （60.5 ±22.1 ）h,which of group B was （52.8 ±19.5）h.The time for rashes on hand and foot recovery of group A was （72.3 ±25.4）h,which of group B was （54.7 ±22.5）h.The average hospitalization time of group A was （124.8 ±42.4）h,which of group was B （108.2 ±36.7）h,and the differences were statistically significant （t =2.45,2.38,2.16,P =0.018,0.015,0.032）. The total effective rate of group B was 93%,which was higher than 85.3% of group A,and the difference was statistically significant （χ2 =6.012,P =0.012）.Conclusion Interferon by aerosol inhalation as a part treatment of hand -foot -and -mouth disease of children （ordinary type）can increase the efficacy rate,shorten course of the disease,accelerate comprehensive rehabilitation of patients.