血尿酸水平与脑梗死合并高血压的相关性

The correlation of blood uric acid in patients with hypertention complicated with cerebral infarct

目的：研究血尿酸水平与脑梗死合并高血压的相关性。方法选取脑梗死合并高血压患者68例，同时选取原发性高血压患者43例为对照组，分别比较其血尿酸（UA）、尿素氮（BUN）、肌酐（Cr）、血糖（GLu）和血脂（TG、TC、HDL、LDL）水平。结果脑梗死合并高血压患者其血尿酸、TG、TC 和 LDL 水平分别为（397．6±89．93）μmol／L、（1．97±1．03）mmol／L、（5．92±1．28）mmol／L 和（2．92±0．85）mmol／L，高于对照组的（342．03±107．48）μmol／L、（1．15±0．89）mmol／L、（4．53±0．75）mmol／L 和（2．41±0．53）mmol／L，差异均有统计学意义（t ＝8．976、3．015、4．758、2．986，均 P ＜0．05）；血尿酸与舒张压水平、血肌酐、TG 升高呈正相关（r ＝0．451、0．768、0．337）。结论高血尿酸血症为脑梗死的危险因素，尤其脑梗死合并高血压患者需定期监测 UA 水平，对无症状高尿酸血症者应积极干预治疗。

Objective To investigate the correlation of blood uric acid in patients with cerebral infarction complicated with hypertention.Methods 68 cerebral infarction patients with hypertention were selected,the other 43 hypertension cases were selected as the contronl group.The uric acid（UA）,blood urea nitrogen（BUN）,serum creatinine（CRE）,glucose（Glu）and total choleststerol（TC）,triglyceride（TG）,high density lipoproteincholerterol （HDL）,low denstiy lipoproteincholerterol（LDL）were compared.Results In the cerebral infarction complicated with hypertention group,the UA,TG,TC and LDL were （397.6 ±89.93）μmol/L,（1.97 ±1.03）mmol/L,（5.92 ± 1.28）mmol/L and （2.92 ±0.85）mmol/L,which were significantly higher than those in the control group[（342.03 ± 107.48）μmol/L,（1.15 ±0.89）mmol/L,（4.53 ±0.75）mmol/L and （2.41 ±0.53）mmol/L,t =8.976,3.015, 4.758,2.986,all P〈0.05 ].There was positive correlation between UA and DBP,BUN,TC（r =0.451,0.768, 0.337）.Conclusion Hypertension is a risk factor of cerebral infarction,especially in patients with cerebral infarc-tion complicated with hypertension need to detect uric acid,asymptomatic hyperuricemia should be treated actively.