孕妇血清同型半胱氨酸、叶酸及维生素 B12水平与妊娠期高血压疾病的相关性研究

The clinical relevance of maternal serum HCY,folic acid and vitamin B12 levels with pregnancy induced hypertension

目的：探讨血清 HCY、叶酸（FA）及维生素 B12（VB12）水平与妊娠高血压综合征（PIH）的临床相关性。方法选择 PIH 孕妇100例，作为观察组；选取同期在该院接受检查的非 PIH 孕妇100例作为对照组。检测两组孕早期、孕中期和孕晚期时血清 HCY、FA 和 VB12水平，并进行比较分析。结果观察组孕早期、孕中期和孕晚期的 HCY 水平分别为（15．07±4．86）μmol／L、（17．82±3．16）μmol／L 和（19．25±3．24）μmol／L，对照组为（6．36±2．47）μmol／L、（5．89±2．14）μmol／L 和（6．68±2．08）μmol／L，观察组产前三个阶段的 HCY 水平均明显高于对照组（t ＝15．97、31．26、32．65，均 P ＜0．05）；两组孕早期的 FA 水平相比，差异无统计学意义（P ＞0．05），观察组孕中期和孕晚期 FA 明显低于对照组（t ＝8．95、11．06，均 P ＜0．05）；观察组产前三个阶段的 VB12水平均明显低于对照组（t ＝4．23、2．53、2．85，均 P ＜0．05）。结论孕中期和孕晚期PIH 孕妇的 FA 和 VB12均缺乏，而 HCY 升高，这可能与 PIH 发生和发展过程相关。

Objective To evaluate the clinical relevance of maternal serum HCY,folic acid （FA）and vitamin B12 （VB12 ）levels with pregnancy induced hypertension （PIH）.Methods 100 pregnant women with PIH were selected as the observation group.100 non -PIH pregnant women at the same period in our hospital were selected as control group.Serum HCY,FA and VB12 levels at trimester,second trimester and third trimester of pregnancy were detected and compared.Results HCY levels at trimester,second trimester and third trimester of pregnancy were （15.07 ±4.86）μmol/L,（17.82 ±3.16）μmol/L and （19.25 ±3.24）μmol/L in the observation group,those were （6.36 ±2.47）μmol/L,（5.89 ±2.14）μmol/L and （6.68 ±2.08）μmol/L in the control group,prenatal HCY levels of the observation group in the three stages were significantly higher （t =15.97,31.26,15.97,all P〈0.05）;the difference FA level at trimester was not statistically significant （P 〉0.05）.FA levels in the observation group at second trimester and third trimester were significantly lower than the control group （t =8.95,11.06,all P〈0.05）.VB12 levels at three stages of prenatal in the observation group were significantly lower than the control group （t =4.23,2.53, 4.23,all P〈0.05）.Conclusion Serum FA and VB12 levels are deficiency at second trimester and third trimester in PIH pregnant women,and with HCY rising,which may associated with the occurance and development of PIH.