2型糖尿病伴冠心病心绞痛患者血栓弹力图分析及其与病情严重程度的相关性分析

Analysis of thrombelastography in type 2 diabetes patients complicated with angina pectoris of coronary heart disease and its correlation with disease severity

目的:分析2型糖尿病伴冠心病心绞痛患者血栓弹力图参数及其与病情严重程度的相关性。方法:选择健康志愿者30例、单纯冠心病心绞痛患者30例、2型糖尿病伴冠心病心绞痛患者30例进行研究,检测血栓弹力图参数R值、K值、α角、MA值以及炎症相关分子YKL-40和NK-kB的表达量。结果:单纯冠心病组和糖尿病合并冠心病组R值、K值低于对照组,α角、MA值高于对照组;糖尿病合并冠心病组R值、K值低于单纯冠心病组,α角、MA值高于单纯冠心病组;2支病变组和3支病变组R值、K值低于1支病变组,α角、MA值以及YKL-40、NK-kB含量高于1支病变组;3支病变组R值、K值低于2支病变组,α角、MA值以及YKL-40、NK-kB含量高于2支病变组;R值、K值与YKL-40、NFkB含量呈负相关,α角、MA值与YKL-40、NF-kB含量呈正相关。结论:2型糖尿病伴冠心病心绞痛患者的血栓弹力图参数显著异常,R值、K值、α角、MA值能够反应病情严重程度以及炎症反应程度。

Objective： To analyze the thrombelastography parameters in type 2 diabetes patients complicated with angina pectoris of coronary heart disease and their correlation with disease severity. Methods： A total of 30 healthy volunteers, 30 patients with simple angina pectoris of coronary heart disease and 30 cases of type 2 diabetes patients complicated with angina pectoris of coronary heart disease were selected for study, thrombelastography parameters including R value, K value, α angle and MA value as well as inflammation-associated molecules YKL-40 and NK-kB expression was detected. Results： R values and K values of simple CHD group and diabetes complicated with CHD group were lower than those of control group, and α angle and MA values were higher than those of control group; R values and K values of diabetes complicated with CHD group were lower than those of simple CHD group, and α angle and MA values were higher than those of simple CHD group; R values and K values of 2 branch lesions group and 3 branch lesions group were lower than those of 1 branch lesion group, and ~ angle and MA values as well as YKL-40 and NK-kB contents were higher than those of 1 branch lesion group; R values and K values of 3 branch lesions group were lower than those of 2 branch lesions group, and a angle and MA values as well as YKL-40 and NK- kB contents were higher than those of 2 branch lesions group; R value and K value were negatively correlated with YKL-40 and NK-kB contents, and a angle and MA value were positively correlated with YKL-40 and NK-kB contents. Conclusion.. Throm- belastography parameters in type 2 diabetes patients complicated with angina pectoris of coronary heart disease are significantly abnormal, and R value, K value, a angle and MA value can reflect disease severity and inflammation degree.