急性脑梗死患者血清炎性因子及血流动力学变化及意义

Changes and significance of serum inflammatory factors and hemodynamics in patients with acute cerebral infarction

目的:探讨急性脑梗死患者血清炎性因子水平及血流动力学指标变化及临床意义。方法:选取本院收治的55例急性脑梗死(ACI)患者作为观察组,及55例健康体检者作为对照组进行研究,采用ELISA法检测炎性细胞因子白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、C-反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)水平,WA-880心脑综合型数字血流动力学监测仪检测双侧颈动脉血流速度、血流量、外周阻力。结果:观察组血清IL-6、IL-8、CRP及TNF-α水平均高于对照组,差异有统计学意义(P<0.05);观察组血流速度、血流量均小于对照组,而外周阻力大于对照组,差异有统计学意义(P<0.05);随着梗死面积的增大,血清IL-6、IL-8、CRP及TNF-α水平呈递增现象,各组间比较有统计学意义(P<0.05);随着梗死面积的增大,血流速度、血流量相应减少,而外周阻力相应增加,各组间比较有统计学意义(P<0.05)。结论:血清炎性因子和血流动力学指标的变化可以用来判断ACI早期脑梗死及梗死面积大小的指标,临床动态监测其变化,对急性脑梗死患者病情严重程度与预后的判断具有重要意义。

Objective： To investigate changes of serum inflammatory factors and hemodynamics in patients with acute cerebral infarction and its clinical significance. Methods： A total of 55 acute cerebral infarction （ACI） patients were enrolled as observation group, and 55 cases of healthy volunteers undergoing physical examination were selected as as control group. ELISA method was used to detect inflammatory cytokines interleukin-6 （IL-6）, interleukin -8 （IL-8）, C- reactive protein （CRP） and tumor necrosis {actor （TNF-α） level, WA-880 heart and brain integrated digital hemodynamic monitor was applied to detect bilateral carotid artery blood flow velocity, blood flow and peripheral resistance. Results： Serum levels of IL-8, CRP, IL-6 and TNF-α were higher in the observation group than that in the control group, the difference was statistically significant （P〈0.05）. The blood flow velocity and blood flow velocity in the observation group were significantly lower than those in the control group. The difference was statistically significant （IL-8）. serum IL-6, CRP, P〈0.05 and TNF-α increased significant- ly with increase of infarct size （P〈0.05）. Conclusion： Changes of serum inflammatory factors and hemodynamic indexes can be used to judge occurrence of early cerebral infarction and the size of the infarct size. Clinical dynamic monitoring of these changes in patients with acute cerebral infarction can help to judge the severity and predict prognosis.