PDMS微流控芯片中的微通道加工技术

Microchannel Processing Technology in PDMS Microfluidic Chips

传统加工方法制作PDMS微流控芯片中的微通道存在诸多限制,特别是难以实现复杂三维微通道的加工。首先介绍了微通道的传统加工方法,接着简要介绍了不同3D打印技术的基本原理,最后重点阐述了3D打印技术在PDMS微流控芯片微通道加工中的应用。未来,微流控芯片中微通道的加工将会向着高通量、低成本、高精度、三维化、集成化、微型化的方向发展。3D打印、以纳米压印为主要代表的微纳制造技术与传统微通道成型技术的不断融合,为研究人员提供了更多的思路,必将成为微通道加工中的重要技术手段,推动微流控芯片在生物医学、检验检疫、分析化学等领域更广泛的应用。

Traditional processing methods have many limitations in the fabrication of microchannels in PDMS microfluidic chips,especially for the complex three-dimensional micro channel.The traditional processing methods of microchannels are firstly introduced,and then the basic principles of different 3D printing technologies are briefly introduced.Finally,the applications of the3 D printing technology in the fabrication of PDMS microfluidic chip microchannels are emphatically expounded.In the future,the fabrication of microchannels in microfluidic chips will develop in the directions of high throughput,low cost,high precision,three-dimensional,integrated and miniaturized.The continuous integration of the 3D printing and micro-nano manufacturing technology with the nanoimprint as the main representative and traditional microchannel molding technology provides more ideas for researchers,and will become an important technical means in the microchannel processing,and promotes the wider application of microfluidic chips in fields of biomedicine,inspection and quarantine,and analytical chemistry.