银杏达莫注射液对慢阻肺急性加重期患者血栓前状态的影响

Clinical research of curative effect of Yinxingdamo in the treatment of chronic obstructive pulmonary disease in prethrombotic state

目的观察银杏达莫注射液(杏丁)对慢性阻塞性肺疾病(简称慢阻肺)急性加重期患者血栓前状态的作用。方法测定103例慢阻肺急性加重期患者血栓前状态指标(PT、TT、APTT、FBG、DD、TAT、PAP),并将其随机分成对照组和治疗组,对照组(48例)给予常规治疗,治疗组(55例)在常规治疗基础上加用银杏达莫注射液25 ml,疗程为14天,复测上述血栓前状态指标。结果对照组治疗前后,血栓前状态指标(PT、TT、APTT、FBG)有改善,但无显著性差异(P>0.05),DD、TAT、PAP指标有显著性差异(P<0.05);治疗组治疗前后PT、APTT、FBG、DD、TAT、PAP指标改善明显(P<0.01),其中治疗组治疗后DD、TAT、PAP指标较对照组治疗后有显著性差异(P<0.05)。结论慢阻肺急性加重期患者联合应用银杏达莫治疗后,可改善其血栓前状态指标,可能改善慢阻肺急性加重期患者预后。

Objective To study the effect of Yinxindamo on coagulation function by observing the change of blood prethrombotic state in the treatment of patients with chronic obstructive pulmonary disease in acute exacerbation state. Methods A total of 103 patients with AECOPD were selected and randomly divided into the control group（ 48cases） and the treatment group（ 55 cases）. The control group was treated with oxygen therapy,spasmolysis,asthmarelief,and sputum reduction,and the treatment group was additionally treated with Yinxindamo 25 ml / day,for 14 days. The blood prethrombotic state indicators of the two groups before and after treatment were determined. Results The differences in PT,TT,APTT and FBG before and after the treatment showed no significance in the control group（ P〉 0. 05）,but the levels of DD,TAT and PAP had significant difference（ P〈 0. 05）. In the treatment group,there were significant differences in PT,APTT,FBG,DD,TAT and PAP before and after the treatment（ P 0. 01）. Meanwhile,the levels of DD,TAT and PAP improved more significantly in the treatment group than in the control group after the treatment（ P〈 0. 05）. Conclusion The conventional therapy combined with Yingxingdamo can improve the blood prethrombotic state indicators of AECOPD patients.