1Wenzel SE. Asthma phenotypes: the evolution from clinical to mo- lecular approaches[J]. Nat Med 2012,18(5) :716 725.
2Nagasaki T, Matsumoto H, Kanemitsu Y,et al. Integrating longi- tudinM information on pulmonary tunction and inflammation using asthma phenotypes[J]. J Allergy Clin Immunol ,2014,133 ( 5 ) : 1474 - 1477.
3Wu W, Bleecker E, Moore W, et al. Unsupervised phenolyping of Severe Asthma Research Program participants using expanded lung data[J]. J Allergy Clin lmmunol 2014, 133 (5):1280- 1288.
4Woodruff PG, Modrek B, Choy DF,et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma [J].Am J Respir Crit Care Med ,2009,180 (5) :388 -- 395.
5Shean J, Aujla, John . TH17 cells in asthma and in flammation [J]. B ioehimieaet Aeta, 2011,1810 ( 11 ) : 1066 - 1079.
7Wenzel SE, Schwartz LB,et al. Evidence that severe asthma can be divided pathologically into lwo inflammatory subtypes with dis- tinct physiologic and clinical characteristics[J]. Am J Respir Crit Care Med 1999,160(3):1001 - 1008.
8Moore WC, Hastie AT, Li X, et al. National Heart, Lung, and Blood Instituteg Severe Asthma Research Program. Sputum neutro- phil counts are associated with more severe asthma phenotypes u- sing cluster analysis [ J ]. J Allergy Clin lmmunol ,2014,133 (6) : 1557 - 1563.
9Irvin C, Zafar I, Good J, et al. Increased fi'equency of dual-posi- tive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma[J].J Allergy Clin Im- munol,2014,134(5) :1175 - 1186.
7Chu HW.Peripheral blood and airway tissure expression of transforming growth factor(beta)by neutrophils in asthmatic subject and normal control subjects.J Allergy Clin Immunol,2000,106:111:5-1123.
8Pasare C,Medzhitov R.Toll pathway-dependent blockade of CD4^+CD25^+T cell-mediated suppression by dendritic cells.Science,2003,299(5609):1033-1036.
9Vignola AM,Campbell AM,Chanez P,et al.HLA-DR and ICAM-1 expression on bronchial epithelial cells in asthma and chronic bronchitis.Am Rev Respir Dis,1993,148:689-694.
10Castellino F,Germain RN.Cooperation between CD4^+ and CD8^+T cells:when,where,and how.Annu Rev Immunol,2006,24:519-540.
