分化型甲状腺癌患者体质量指数与瘦素表达的相关性

Study on the relationship between body mass index and Leptin expression in patients with differentiated thyroid carcinoma

目的:探讨体质量指数与甲状腺癌组织瘦素(Leptin)表达水平的相关性,为临床诊断及治疗分化型甲状腺癌提供依据。方法:选择分化型甲状腺癌患者167例,根据体质量指数分为体重正常组(n=64)、超重组(n=47)和肥胖组(n=56),观察各组的甲状腺组织Leptin及其受体(OB-R)表达水平。结果:正常组的肿瘤大小以<1cm为主,而肥胖组则以≥1cm居多(P<0.05);正常组肿瘤分期I、Ⅱ期比例居多,肥胖组以Ⅲ、Ⅳ期为主(P<0.05);三组患者的Leptin、OB-R表达水平随着患者体质量指数的增加而逐渐升高(P<0.05);甲状腺癌患者体质量指数与Leptin表达水平呈正相关。结论:Leptin与甲状腺癌的发生、进展密切相关,同时Leptin与患者体质量指数密切相关。

Objective：To investigate the correlation between body mass index and Leptin expression in thyroid cancer of patients with differentiated thyroid carcinoma. Methods ：There were 167 patients with differentiated thyroid carcinoma were selected, according to body mass index, they were divided into normal group （n = 64）, over group （n = 47 ） and obesity group （ n = 56 ）. The changes of Leptin expression level in each group was observed. Results ： The tumor size of normal group were dominated by 〈 1 cm, that of obese group were dominated by ≥ I cm（ P 〈 0.05 ）. The percentage of Ⅰ and Ⅱ phase tumor stage in normal group was major, and the percentage of Ⅲ, Ⅳ stage in obesity group was major（ P 〈 0.05 ）. With patients＇ body mass index increasing in there group, they increased gradually （P 〈 0.05 ）. Conclusion：There is a close correlation between Leptin and thyroid carcinogenesis. Obesity may promote the combination of Leptin and OB - R through a variety of mechanisms, activating related signal pathway in thyroid tissue, eventually lead to thyroid cancer.