三阴性乳腺癌患者外周血中TGF-β1含量与其临床特征及预后的关系

The relationship between TGF- β1 in three negative breast cancer patients and relation with prognosis

目的:研究乳腺癌患者在治疗前后外周血中TGF-β1蛋白含量变化,初步探讨TGF-β1含量与其临床特征及预后之间的关系。方法:酶联免疫吸附实验测定三阴性乳腺癌患者治疗前后外周血中TGF-β1蛋白含量变化。并随访5年内的无瘤生存时间。研究TGF-β1浓度的变化与各项临床特征及其预后之间的关系。结果:三阴性乳腺癌组患者外周血中TGF-β1蛋白的含量显著高于非三阴型乳腺癌组,且经过有效的治疗后,其含量由(108.43±10.55)ng/L降至为(58.41±10.78)ng/L,与治疗前比具有统计学差异(P=0.000)。TGF-β1的含量在不同年龄、绝经状态、肿瘤家族史、肿瘤大小等方面无显著差异,但与肿瘤的组织学分级及腋下淋巴结转移与否有显著的关联,其含量越高,5年内无瘤生存时间越短。结论:三阴性乳腺癌患者外周血中TGF-β1的含量显著增高,与肿瘤组织学分级及腋下淋巴结是否转移显著正相关,与5年无瘤生存时间呈负相关,能够为乳腺癌的临床治疗、预后判断提供新的靶点及思路。

Objective：To study the change of of TGF - β1 content in peripheral blood of three negative breast cancer（TNBC） before and after treatment, to explore the relationship between TGF -β1 and its clinical characteristics and prognosis. Methods：Changes of TGF - β1 content were measured in peripheral blood before and after the treatment of breast cancer patients by enzyme linked immunosorbent assay, tumor free survival time was followed up for 5 years. Results：The contents of TGF- β1 in peripheral blood of TNBC was significantly higher than that of the three negative breast cancer group. After treatment, the content decreased significantly. There were no significant differences of TGF - β1 in different age, menopausal status, family history of cancer, tumor size, but in the tumor histo- logical grade and axillary lymph node metastasis was significantly associated with it, its content was higher, 5 years disease - free survival time was short. Conclusion：The content of TGF - β1 in peripheral blood of TNBC was significantly increased, and tumor histological grade and axillary lymph nodes metastasis had significantly positive correlation, negative correlation with the five year tumor free survival time. It can provide new target and idea to determine prognosis of breast cancer.