血清肿瘤相关物质检测在骨肿瘤诊断中的应用

Serum tumor associated material detection in the diagnosis of bone tumors

目的:了解血清肿瘤相关物质(serum tumor associated material,TAM)在骨肿瘤患者中的表达情况,及其表达在骨原发恶性肿瘤及骨转移瘤中的意义。方法:对2012-2014年间郑州大学第一附属医院骨科200例瘤患者临床TAM检验值数据采集分组并进行统计学分析从而得出结论。结果:良性肿瘤组(A组)TAM表达平均值(86.36±6.873)U/ml,阳性率8%;恶性肿瘤组(B组)平均值(108.28±21.603)U/ml,阳性率80%;转移瘤组(C组)平均值(111.04±16.744)U/ml,阳性率84%;非肿瘤组(D组)平均值(87.5±6.438)U/ml,阳性率6%。TAM平均值A组与D组之间、B组与C组之间无显著差异,A、D两组与B、C两组之间两两差异显著。TAM检测值阳性率A、D两组与B、C两组的差异均具有统计学意义,A组与D组、B组与C组的差异不具有统计学意义。结论:TAM是一敏感性高,广谱、价廉、检查方便的肿瘤相关物质,在骨原发恶性肿瘤及骨转移瘤中明显高于骨良性肿瘤及良性病变的检测值,阳性率高达80%以上。

Objective：To study the serum tumor associated material （TAM） on the expression of bone tumors crowd, and its expression in primary malignant tumor of bone and bone metastases. Methods： To collect the data of the First Affiliated Hospital of Zhengzhou University from 2012 to 2014 for 200 patients with TAM. Results ： In benign tumor group （group A）, the TAM expression measured average was （86.36 ±6. 873）U/ml, positive rate 8%, malignant tumor group （ group B） the measured average （ 108.28 ± 21. 603 ） U/ml, positive rate 80%, metastases group （ group C） measured average （ 111.04 ± 16. 744 ） U/ml, positive rate 84%, non - tumor group （ group D） measured average （87.5±6. 438） U/ml, positive rate 6%. TAM had no significant difference and was not statistically significant between group A and group D, so was group B and group C. Group B/C and group A/D had remarkable difference. TAM had statistically significant differences in group A/D and group B/C. Conclusion：TAM is a tumor related substances with high sensitivity, broad spectrum ,low price and easy to check. The positive rate in the primary malignant tumor of bone and bone metastases was obvious higher than that of benign tumor,which was as high as 80% or above.