雌激素受体和孕激素受体在妊娠期高血压疾病胎盘组织中的表达

Expressions of estrogen receptor and progestin receptor in the placenta of human hypertensive disorders complicating pregnancy

目的探讨雌激素受体(estrogen receptor,ER)和孕激素受体(progestwrone receptor,PR)在妊娠高血压疾病(HDCP)胎盘组织中的表达。方法应用免疫组化法和Western blotting法,以正常剖宫产分娩孕妇25例为对照,检测50例轻度子痫前期和重度子痫前期患者胎盘组织中ER及PR的表达情况。结果 SER和PR在轻度子痫前期和重度子痫前期患者胎盘组织中表达比正常剖宫产患者胎盘组织中表达显著降低(<0.05),并且ER在重度子痫前期患者胎盘组织中表达下降更为显著(<0.05)。结论 ER及PR在HDCP胎盘组织中低表达。

Objective To study the expressions of estrogen receptor（ER） and progestin receptor（PR） in the placenta of human hypertensive disorders complicating pregnancy（HDCP） and normal pregnancy. Methods The expressions of ER and PR in placenta were detected by immunohistochemistry and Western blot. Results The expression levels of ER and PR in placenta were significantly lower in HDCP with pre-eclampsia than in normal pregnancy（P〈0.05）, with more lower for ER but not for PR. Conclusion ER and PR were lower espressed in placenta of HDCP.