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雌激素受体和孕激素受体在妊娠期高血压疾病胎盘组织中的表达 被引量:7

Expressions of estrogen receptor and progestin receptor in the placenta of human hypertensive disorders complicating pregnancy
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摘要 目的探讨雌激素受体(estrogen receptor,ER)和孕激素受体(progestwrone receptor,PR)在妊娠高血压疾病(HDCP)胎盘组织中的表达。方法应用免疫组化法和Western blotting法,以正常剖宫产分娩孕妇25例为对照,检测50例轻度子痫前期和重度子痫前期患者胎盘组织中ER及PR的表达情况。结果 SER和PR在轻度子痫前期和重度子痫前期患者胎盘组织中表达比正常剖宫产患者胎盘组织中表达显著降低(<0.05),并且ER在重度子痫前期患者胎盘组织中表达下降更为显著(<0.05)。结论 ER及PR在HDCP胎盘组织中低表达。 Objective To study the expressions of estrogen receptor(ER) and progestin receptor(PR) in the placenta of human hypertensive disorders complicating pregnancy(HDCP) and normal pregnancy. Methods The expressions of ER and PR in placenta were detected by immunohistochemistry and Western blot. Results The expression levels of ER and PR in placenta were significantly lower in HDCP with pre-eclampsia than in normal pregnancy(P〈0.05), with more lower for ER but not for PR. Conclusion ER and PR were lower espressed in placenta of HDCP.
出处 《解剖科学进展》 2015年第6期621-623,共3页 Progress of Anatomical Sciences
基金 辽宁省科技厅自然基金(2013022006)
关键词 人妊娠期高血压疾病 孕激素受体 雌激素受体 human hypertensive disorders complicating pregnancy estrogen receptor progestin receptor
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参考文献8

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二级参考文献4

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