Microbial specific carboxylation of (–)-huperzine A by Streptomyces griseus

灰色链霉菌对(-)-石杉碱甲的选择性羧基化（英文）

In a scale-up microbial transformation of（–）-huperzine A（1） by Streptomyces griseus CACC 200300, a specific carboxylated derivative（2） was yielded together with two known hydroxylated metabolites. The structure of 2 was characterized as 16-carboxyl huperzine A on the basis of IR, HRMS and NMR spectroscopic data analysis.

利用灰色链霉菌(Streptomyces griseus CACC 200300)对(-)-石杉碱甲(1)进行放大生物转化获得了一个新的位置选择性羧基化产物(2)和两个已知羟基化产物,经红外光谱、高分辨质谱以及核磁共振波谱分析,新化合物的结构被鉴定为16-羧基石杉碱甲(2)。