芫花酯乙和黄芫花提出液对EB病毒早期抗原的诱导和促进EB病毒对淋巴细胞转化的研究

EPSTEIN-BARR VIRUS EARLY ANTIGEN INDUCTION AND ENHENCEMENT OF LYMPHOCYTE TRANSFORMATION BY YUANHUADINE Ⅱ AND WIKSTROEMIA CHAMAEDAPHNE

本研究证明,用于妊娠引产的药物芫花酯乙和黄芫花提出液,能诱导Raji细胞内EB病毒的早期抗原(EA),并能促进EB病毒对淋巴细胞的转化作用。维生素甲衍生物7901能明显地抑制这两种药物诱导EA的作用。这些特性与已知的促癌物质TPA是一致的。

Yuanhuadine Ⅱ and extract of Wikstroemia Chamaedaphne used for abortlfa'cient could induce EB virus early antigen In Raji cells and enhance the lymphocytes trasformatlon by EB virus. Induction of EB virus early antigen after treatment with Yuanhuadine Ⅱ and Wiksiroemia Chamaedaphne was markedly Inhibited by retinold 7901. These properties of both drugs were similar to tumor promotor TPA.