美罗培南不同输注方式治疗重症肺炎的疗效观察

Clinical Observation on Therapeutic Effect of Meropenem in Treatment of Severe Pneumonia Through Different Infusion Methods

目的观察美罗培南不同输注方式治疗重症肺炎的临床疗效。方法选取ICU重症肺炎患者40例,随机分为两组:对照组和治疗组。对照组的输注方案为美罗培南1g溶于0.9%的生理盐水100m L中,经30min静脉点滴给药;治疗组的输注方案为美罗培南1g溶于0.9%的生理盐水50 ml中,微量推注泵持续3h泵入。比较两组患者的体温和白细胞变化值、临床疗效、病原学疗效及不良反应发生率等相关指标。结果给药72h后,白细胞计数变化值两组间比较无统计学意义(P>0.05);体温下降幅度治疗组高于对照组(P<0.05)。停药当天,治疗组临床有效率及细菌清除率高于对照组P<0.05。结论美罗培南3h持续泵入给药方案治疗重症肺炎的疗效优于30min静脉点滴给药。

Objective To investigate the efficacy of different infusion methods of meropenem in the treatment of severe pneumonia.Methods 40 cases of patients with severe pneumonia form ICU, were randomly divided into treatment group and control group. In the control group, meropenem 1g was added into 100 m L NS intravenous infusion for 30 minutes, every 8 hours at a time.In the treatment group,meropenem 1g was added into 50 m L NS using micro pump intravenously for 3 hours, every 8 hours at a time.Other treatment were expectorant, life support and nutritional support and other symptomatic treatment. At last, the changes of body temperature and white blood cell count; the bacterial clearance rate; the incidence of adverse reactions and another indicators of the two groups were compared. Results After 72 hours of meropenem administration, no significant difference was obeserved on white blood cell counts of the two groups（P〈0.05）;compared with control group, the temperature in treatment group significantly dereased（P〈0.05）; On the withdrawal day, the clinical efficiency and bacterial clearance rate were treatment group than control group（P〈0.05）. Conclusion Meropenem in the way of 3 hour infusion on severe pneumonia＇s treatment has better efficacy than that of 30 minutes infusion.