TRPM离子通道与人类疾病

TRPM Ion Channels and Human Diseases

TRPM蛋白家族是一类表达于多种哺乳动物细胞中广泛存在的离子通道。近年来发现它们在维持某些特定生理功能中起关键作用且与人类疾病密切相关。研究显示氧化应激可使TRPM离子通道功能异常导致疾病发生、发展。TRPM亚家族的三个成员,TRPM2,TRPM4和TRPM7均受氧化应激的调控,其功能改变、增加或缺失与炎症及免疫系统的激活、神经退行性疾病和神经系统疾病、心血管疾病、癌症及糖尿病,代谢紊乱和骨疾病等疾病紧密联系。本文就近年来氧化应激调控的TRPM离子通道与人类疾病的关系做简要综述。此外,文章也将探讨它们作为药物设计靶点和工具的应用前景。

The transient receptor potential melastatin （TRPM） protein family is an extensive group of ion channels expressed in several types of mammalian cells. Many studies have shown that these channels are pivotal for performing several physiological functions and involving in numerous human diseases. Increases, absences, or modifications of the oxidative stress-modulated TRPM ion channels, TRPM2, TRPM4, and TRPM7 are also involved in numerous human diseases, known as inflammation and immune system activation, neurodegenerative diseases and neurological disorders, heart and vascular diseases, cancer and diabetes, metabolic disorders and bone disease. The most relevant findings regarding the participation of the oxidative stress-modulated TRPM ion channels in human diseases are examined and the potential roles of these channels as therapeutic tools and targets for drug design are discussed in this review.