重复经颅磁刺激对帕金森病抑郁患者的生活质量及运动症状疗效的影响

The effect of repetitive transcranial magnetic stimulation on the quality of life and efficacy of motor symptoms in patients with depression in Parkinson disease

目的探讨经颅磁刺激对帕金森病抑郁（dPD）患者生活质量及运动症状疗效的影响。方法回顾性分析2011年2月-2015年1月收入的286例dPD患者的病历和随访资料,其中168例加行重复经颅磁刺激治疗（治疗组）,余118例仅行常规药物治疗（对照组）,采用Student＇s t或卡方检验比较两组的生活质量SF-36量表评分和运动症状疗效。结果治疗后,两组患者的生活质量都得到改善（P均〈0.05）,治疗组患者的心理健康（t=4.44,P〈0.01）、情绪角色功能（t=2.47,P=0.01）和精力（t=4.45,P〈0.01）等生活质量评分显著高于对照组;治疗组的PD运动症状疗效的特别显效率高于对照组（χ^2=4.73,P=0.03）。结论重复经颅磁刺激可显著提高dPD患者生活质量,且在心理、情绪和精力方面的效果优于常规药物治疗,此外,它对PD运动症状的改善也有一定影响。

Objective To explore the effect of repetitive transcranial magnetic stimulation on the quality of life and efficacy of motor symptoms in patients with depression in Parkinson disease. Methods A retrospective analysis of medical records and follow-up data of 286 dPD patients included during February 2011-January 2015,the patients divided into repetitive transcranial magnetic stimulation group （treatment, N= 168） and conventional drugs group （control, N= 118） ,then student＇s t or Chi-square test were used to compare the SF-36 quality of life scores and efficacy of motor symptoms between two groups. Results After treatment, the quality of life in two groups were improved （P〈0. 05）, mental health treatment group patients （t=4. 44, P〈0.01） ,emotional role function （t=2. 47,P=0. 01） and energy （t=4. 45,P〈0. 01） scores were significantly higher in treatment group; the particular efficiency of motor symptoms was significantly higher in treatment group （χ^2=4. 73,P=0. 03）. Conclusion Repetitive transcranial magnetic stimulation can significantly improve the quality of life in dPD patients, especially in psychological,emotional and energy aspects, in addition, it also have some impact in improved motor symptoms of PD.