绝经前后子宫内膜癌生存因素分析

survival factors of premenopausal and postmenopausal endometrial cancer

目的:探讨绝经前后子宫内膜癌的临床资料及预后相关因素。方法:选取2008年1月至2012年3月在唐山市妇幼保健院诊断为子宫内膜腺癌,并接受了手术方法治疗的患者240例。随访共36个月,至2015年3月,分为绝经前和绝经后两组。绝经前115例,绝经后125例,比较两组患者的临床特征、单因素分析两组影响子宫内膜癌患者的预后相关因素及两组间生存率差异。结果:本研究显示绝经前组和绝经后组子宫内膜癌在腺癌类型、深肌层浸润、宫颈受累、淋巴转移、附件受累、病理分级例数、ER、PR阳性例数,比较两者均差异无显著性(P>0.05)。两组患者的组织类型、浸润深度、病理分级、附件转移、宫颈受累是影响子宫内膜癌预后的独立因素。绝经前与绝经后患者的3年生存率分别为87%、72%,P<0.05,有明显统计学意义。结论:绝经前后子宫内膜癌预后差异显著,绝经是预后的独立因素。

Objective： To investigate the prognosis related factors of premenopausal and postmenopausal endometrial cancer after 3 years of endometrial cancer surgery. Methods： All 240 endometrial adenocarcinoma cases with operation were divided into two groups before and after menopause groups,115 cases of premenopausal,125 postmenopausal cases,clinical features. Results： In the premenopausal group and postmenopausal group,there were no difference in cancer type,depth of myometrial invasion,cervical invasion,lymph node metastasis,adnexal involvement,pathological grading,ER cases,PR positive cases.（ P〉0. 05）. The two groups of patients in the histological type,depth of invasion,pathological grading,adnexa metastasis,cervical involvement were independent prognostic factors of endometrial carcinoma. The 3 year survival rate of the patients with menopause group and non menopause group were 72%,87%,there was statistical significance. Conclusion： The prognosis of endometrial carcinoma before and after menopause menopause is significantey different,and to be independent prognostic factors.