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自身免疫病新靶标Kv1.3及其药用多肽研究进展 被引量：1

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摘要 自身免疫病是机体对自身抗原发生免疫反应而导致自身组织出现临床损害所引起的疾病。全球有5％-8％的人口受到约40种自身免疫性疾病的威胁，目前尚无特效疗法，且病情易反复发作。
作者 丁莉 李健 吴英亮 陈宗运
机构地区 湖北医药学院基础医学院生物化学教研室寄生虫学教研室 武汉大学生命科学学院病毒学国家重点实验室
出处 《湖北医药学院学报》 CAS 2015年第5期506-512,F0004,共8页 Journal of Hubei University of Medicine
基金 国家自然科学基金(31200557)
关键词 Kv1.3钾通道 自身免疫疾病 动物模型 多肽药物
分类号 R593.2 [医药卫生—内科学]
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参考文献70

  • 1Wahren-Herlenius M, Dorner T. Immunopathogenic mechanisms of systemic autoimmune disease [ J ]. Lan- cet,2013,382(9 894) :819 - 831.
  • 2Cahalan MD, Wulff H, Chandy KG. Molecular properties and physiological roles of ion channels in the immune system[ J]. J Clin Immunol,2001,21 (4) :235 - 252.
  • 3Kazama I. Roles of lymphocyte Kvl. 3-channels in gut mucosal immune system:Novel therapeutic implications for inflammatory bowel disease [ J ]. Med Hypotheses, 2015,85 ( 1 ) :61 - 63.
  • 4Jang SH, Byun JK, Jeon WI, et al. Nuclear localization and functional characteristics of voltage-gated potassium channel Kvl. 3[ J]. J Biol Chem, 2015,290 (20) : 12 547 - 12 557.
  • 5Kazama I. Physiological significance of delayed rectifier K( + ) channels ( Kvl. 3 ) expressed in T lymphoeytes and their pathological significance in chronic kidney disease [ J ]. J Physiol Sci ;2015,65 ( 1 ) : 25 - 35.
  • 6Chandy KG, Cahalan M, Pennington M, et al. Potassium channels in T lymphocytes:toxins to therapeutic immuno- suppressants [ J ]. Toxicon ,2001,39 (9) : 1 269 - 1 276.
  • 7胡明,逄越,刘欣,李庆伟.Kv1.3通道阻滞剂与T、B淋巴细胞介导的自身免疫疾病[J].免疫学杂志,2010,26(4):356-361. 被引量：6
  • 8DeCoursey TE, Chandy KG, Gupta S, et al. Voltage-gated K+ channels in human T lymphocytes:a role in mitogene- sis? [J]. Nature,1984,307(5 950) :465 -468.
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二级参考文献78

  • 1张利方,郑山根,周萍.自身免疫性肝病患者自身抗体检测及临床意义[J].免疫学杂志,2009,25(2):202-204. 被引量：16
  • 2张宗明,裘法祖.离子通道与疾病[J].世界华人消化杂志,2005,13(5):585-587. 被引量：21
  • 3Gutman GA, Chandy KG, Adelman JP, et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels [J]. Pharmacol Rev, 2003,55(4): 583-586.
  • 4Lewis RS. Calcium signaling mechanisms in T lymphocytes [J]. Annu Rev Immunol, 2001, 19: 497-521.
  • 5Rus H, Pardo CA, Hu L, et al. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infil- trates in multiple sclerosis brain [J]. PNAS, 2005,102(31): 11094-11099.
  • 6Matheu MP, Beeton C, Garcia A, et al. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block [J]. Immunity, 2008, 29 (4): 602-614.
  • 7Beeton C, Pennington MW, Wulff H, et al. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases [J]. Mol Pharmacol, 2005, 67 (4): 1369-1381.
  • 8Beeton C, Barbaria J, Giraud P, et al. Selective blocking of voltage-gated K^+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation[J]. Immunol, 2001, 166 (2), 936-944.
  • 9Beeton C, Chandy KG. Potassium channels, memory T cells, and multiple sclerosis [J]. Neuroscientist, 2005, 11 (6): 550-562.
  • 10Fujinami RS, von Herrath MG, Christen U, et al. Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease[J]. Clin Microbiol Rev, 2006, 19 (1): 80-94.

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湖北医药学院学报
2015年 第5期

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