阿托伐他汀治疗高血脂的临床疗效分析

Analysis of the clinical efficacy of atorvastatin in the treatment of high blood cholesterol

目的探讨高血脂患者应用阿托伐他汀治疗的临床效果。方法将260例高血脂患者随机分为对照组和研究组,各130例。两组患者均进行低脂饮食、运动指导等基础治疗。对照组患者给予辛伐他汀治疗,研究组患者给予阿托伐他汀治疗,治疗2个月后,比较两组患者治疗前后的血脂情况。结果治疗前两组患者TG、TC、LDL-C、HDL-C差异无统计学意义(P>0.05);治疗后,研究组患者HDL-C明显高于对照组,TG、TC、LDL-C明显低于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率差异无统计学意义(P>0.05)。结论对于高血脂患者,辛伐他汀与阿托伐他汀均具有较高的安全性,但阿托伐他汀的降血脂效果更好。

Objective To investigate the clinical efficacy of atorvastatin in the treatment of patients with high blood cholesterol. Methods 260 patients with high cholesterol were randomly divided into control group and research group. Both groups were given basic treatment as low - fat diet, exercise instruction and so on. The control group was treated with simvastatin, and the research group was given atorvastatin. The lipid profile of the two groups were compared before and after the treatment. Results Before treatment, there was no significant difference in TG, TC, LDL - C, HDL - C （ P 〉 0.05 ）. After treatment, HDL - C values of research group were significantly higher than the control group, while TG, TC, LDL - C values were significantly lower than the control group, The difference was statistically significant（P 〈 0.05）. There was no significant difference in the prevalence of adverse effects between the two groups （P 〉 0.05）. Conclusion For patients with high blood cholesterol, both simvastatin and atorvastatin have high security, but atorvastatin has a better lipid -lowering effect.