导航辅助内镜下经鼻蝶窦垂体瘤切除术的疗效分析

Efficacy of endoscopic resection for pituitary tumors though sphenoid sinus via nasal by navigation aids

目的研究导航辅助内镜下经鼻蝶窦垂体瘤切除术的临床疗效。方法选择2012年6月到2013年6月接诊的100例需行垂体瘤切除术患者进行研究。随机分为观察组和对照组。观察组50例患者行导航辅助内镜下经鼻蝶窦垂体瘤切除术。对照组50例患者采用常规经鼻前庭蝶窦手术进行治疗。比较两组患者术后情况、手术时间、术中出血量及住院时间、并发症以及临床总有效率。结果观察组患者在术后激素下降程度、肿瘤残留、肿瘤体积减少的程度明显优于对照组(P<0.05);观察组的手术时间以及住院时间均少于对照组(P<0.05)。观察组患者术后并发症发生比率(18.0%)明显少于对照组(34.0%)(P<0.05);观察组患者复发率为2.0%明显少于(14.0%)(P<0.05);观察组患儿总有效率(94.0%)明显高于对照组(74.0%)(P<0.05)。结论导航辅助内镜下经鼻蝶窦垂体瘤切除术的疗效良好,并能缩短病程,减少并发症与复发,值得临床推广。

Objective To study the effect of endoscopic resection of pituitary tumors for sphenoid sinus via nasal by navigation aids. Methods 100 patients associated with endoscopic resection of pituitary tumors from June 2012 to June 2013 in our hospital were researched. They were divided randomly into observation and control groups. 50 patients in the observation group, they were treated by endoscopic resection for pitui- tary tumors though sphenoid sinus via nasal by navigation aids. 50 patients in the control group received conventional nasal vestibule sphenoid sinus surgery treatment. The situation, operative time, blood loss and hospital stay, complications, and clinical total efficiency of two groups of patients after surgery were compared. Results The postoperative hormone decline extent of residual tumor were observed. The degree of reduction in tumor volume was significantly better than the control group, the two groups was statistically significant （ P 〈 0.05 ）. The operation time and the time of staying hospital of observation group were less than the control group （ P 〈 0.05 ）. Postoperative complications occurred in patients in the observa- tion group ratio （18.0%） , which was significantly less than the control group （34.0%） , the two groups was statistically significant （ P 〈 O. 05 ）. The relapse rate of patients in the observation group and the control group 2.00% and 14.00%. The two groups was statistically significant （ P 〈 0.05 ）. The total efficiency of the children in the observation group （94.0%） was significantly higher （74.0%）. Compare two sets of data were statistically significant （ P 〈 0.05）. Conclusion The effect of endoscopic resection of pituitary tumors for sphenoid sinus via nasal by navigation aids is well, and it can shorten the course, reduce complications and reduce the recurrence of proportion. It is worthy of promotion in clinic.