糖尿病肾病治疗的循证医学新进展

New advancements of evidenced-based medical treatment of diabetic nephropathy

随着糖尿病(DM)发病率的逐年上升,糖尿病肾病(DN)已成为引起我国乃至全球终末期肾病的一个主要原因,因此其治疗问题也成为临床肾脏病学界的一个重要焦点。近年来,DN治疗的循证医学研究取得了一些新的进展,如合理地控制血糖、血压,调节血脂,降低蛋白尿,保护肾功能等治疗措施的更新,在一定程度上改变了人们以往对DN治疗的认识。对防治DN并发症,延缓DN进展,降低患者心血管疾病及死亡发生率具有重要的临床价值。该文结合文献资料及我们以往的工作对DN治疗循证医学新进展予以综述。

With the increasing incidence of diabetes mellitus （DM） year by year, diabetic nephropathy （DN） has become one of the major causes of end-stage renal disease in the world. Therefore, its medical treatment has become the focus of attention. Recently, new advancements in evidence- based treatment of DN have been shown in reasonably controlling hyperglycemia, hypertension, dyslipidemia, reducing proteinuria, and protecting renal function. These measures have updated the previous recognition of treatments, and have significant clinical value in prevention and treatment of complications, slowing down the progression of DN, and reducing the incidence of cardiovascular diseases and death. Here we reviewed the new advancements of evidenced-based treatment of diabetic nephropathy according to the related publications.