视黄酸的结构、代谢、受体及其与器官发育的关系

The structure,metabolism,receptors of retinoic acid and its relationship with organ development

维生素A是一种人体必需脂溶性维生素,主要通过其代谢产物视黄酸发挥作用,视黄酸对于器官的形成与分化、组织细胞的增生与凋亡起着重要作用,其摄入不足或过量均会引起组织器官发育异常。本文就视黄酸的分子结构、代谢过程、视黄酸受体以及视黄酸与器官发育的关系作一综述,旨在提高对视黄酸与组织器官发育关系的认识。

Vitamin A is a kind of essential fat-soluble vitamin in human body. Retinoic acid （RA）, the main metabolite of vitamin A, plays an important role in the formation and differentiation of organs and the proliferation and apoptosis of tissue or cells. The deficiency or excess intake of RA will cause abnormal development of tissues and organs. The present paper has reviewed the molecular structure, metabolism process, receptors of RA, and the interaction between RA and organ development, in order to improve recognization of the relationship between RA and the development of organs.