进展期乳腺癌中HER2和IGF1R的蛋白表达及其临床意义

Study on the clinical significance of protein expression of HER2 and IGF1R in patients with advanced breast cancer

目的探讨进展期乳腺癌中原癌基因人类表皮生长因子受体2(HER2)和胰岛素样生长因子1受体(IGF1R)的蛋白表达水平及其与病理分型、病理分化程度及TNM临床分期的相关性,其与生存期的关系。方法使用免疫组织化学方法,对68例进展期乳腺癌患者手术切除标本进行HER2和IGF1R蛋白表达水平的检测,对以上患者进行临床随访,使用非参数检验检测其与临床病理资料的相关性,Spearman相关系数检测二种蛋白表达水平之间的相关性,使用生存函数分析HER2和IGF1R表达水平与生存期间的关系。结果在68例进展期乳腺癌手术切除标本中,Her2和IGF1R的阳性表达率分别为39.7%(27/68)和58.8%(40/68);二者的表达水平与病理类型和病理分化程度相关;IGF1R的表达水平与年龄相关。HER2和IGF1R的表达水平与生存期具有显著的正相关(P=0.086,P=0.001),且二者在表达水平方面具有显著相关性(P=0.003)。结论 HER2和IGF1R的阳性表达提示进展期乳腺癌的预后较好,二者呈明显的正相关。

Objective To explore the relationship among levels of protein expression of HER2 and IGF1 R and pathological classification,degree of pathological differentiation,TNM clinical staging,and the duration of survival of patients with advanced breast cancer. Methods The detection of protein expression of HER2 and IGF1 R in dissected tissue specimens of 68 patients with advanced breast cancer had been examined by immunohistochemical method,and these patients had been followed up for getting their later massage. Spearman correlation coefficient had been applied to study the correlation between expression level of protein and clinical pathological data by using SPSS 19.0 for statistical analysis. Results In samples of resected tissue of advanced breast cancer,the positive expression rates of HER2 and IGF1 R were 39.7 %（ 27/68） and 58.8%（ 40 /68） respectively. Both of them were correlated with pathological type and pathological differentiation. The expression level of IGF1 R was related with the age range of patients. The expression levels of HER2 and IGF1 R were correlated with the range of survival（ P = 0.086,P = 0.001）,and they were related to each other in protein expression level（ P = 0. 003）. Conclusion The positive expression of IGF1 R and HER2 is associated with the favorable prognosis of patients with advanced breast cancer.