ADAM33基因V4位点多态性与儿童哮喘易感性的关系

Association between ADAM33 V4 polymorphsim and susceptibility in childhood asthma: a meta-analysis

目的综合评价解整合素金属蛋白酶33(ADAM33)基因V4位点多态性与儿童哮喘易感性的关系。方法制定统一的检索策略,检索Pubmed、Ovid-Medline、Embase、CNKI、维普及万方数据库中有关ADAM33基因多态性与哮喘易感性关系的病例-对照研究,按照纳入和排除标准选择文献提取相关信息,应用Review Manager 5.0软件进行Meta分析。纳入6篇合格文献,均满足遗传平衡检验,累计1435例儿童哮喘病例和1710例对照。结果在等位基因模型、显性模型和隐性模型中,ADAM33基因V4位点多态性与儿童支气管哮喘的易患性无关(G与C:OR=1.33,95%CI=0.96-1.84,P=0.09;CG+GG与CC:OR=1.41,95%CI=0.95-2.08,P=0.09;CC+CG与GG:OR=0.47,95%CI=0.18-1.22,P=0.12)。结论 ADAM33基因V4位点多态性与儿童支气管哮喘的易感性无相关性。

Objective To study whether the polymorphisms of V4 in ADAM33 （A Disintegrin and Metalloproteinase 33） gene contribute to the susceptibility to childhood asthma.Methods According to the same criteria, all the clinical studies related to the polymorphism of ADAM33 gene and asthma were searched through PubMed, Ovid-Medline, Embase、CNKI, Wanfang and Weipu data-bases.All retrieved articles were screened and evaluated followed by meta-analysis using RevMan 5 software.Results Six studies were included based on the selection criteria.In these studies, 1435 childhood asthma and 1710 controls were identified and all control group genotype frequencies were consistent with Hardy-Weinberg equilibrium.By meta-analysis, in allele and dominant models and re-cessive models,ADAM33 gene V4 polymorphism was not related to liability of childhood asthma （ G与C：OR=1.33,95%CI=0.96-1.84,P=0.09;CG＋GG与CC：OR=1.41,95%CI=0.95-2.08,P=0.09;CC＋CG与GG：OR=0.47,95%CI=0.18-1.22, P=0.12）.Conclusion Polymorphism of ADAM33 V4 seems not to be involved in elevated risk of childhood asthma.