细胞因子诱导杀伤细胞联合树突状细胞生物治疗辅助化疗对胃癌术后患者的治疗效果

Efficacy of cytokine induced killer cells with dendritic cells biological treatment and chemotherapy for patients with gastric cancer underwent surgery

目的观察细胞因子诱导杀伤细胞联合树突状细胞(DC-CIK)生物治疗辅助化疗对胃癌术后患者的治疗效果。方法将180例胃癌患者根据治疗方式不同分为观察组和对照组,观察组患者应用DC-CIK联合胃癌根治术及TP方案(紫杉醇+顺铂)化疗,对照组患者仅采用胃癌根治术及TP方案化疗,观察并比较两组患者的不良反应发生情况和3年生存率。结果两组患者治疗后干扰素γ(INF-γ)水平均高于治疗前(均P<0.05)。两组患者不良反应发生率差异无统计学意义(P>0.05);两组患者3年总生存率差异无统计学意义(P>0.05)。观察组患者的进展期生存率明显高于对照组,差异有统计学意义(P<0.05)。结论 DC-CIK生物治疗辅助胃癌术后化疗能够提高细胞因子水平,并且可有效地提高胃癌术后患者进展期生存率。

Objective To observe the effect of cytokine induced killer cells with dendritic cells（ DC-CIK） biological treatment and chemotherapy for patients with gastric cancer underwent surgery. Methods Sixty gastric cancer patients were divided into the observation group and the control group according to the treatment methods. The observation group were treated with DC-CIK combined with chemotherapy on postoperative gastric cancer. The patients in the control group only received chemotherapy after operation.The curative effect,adverse reactions and the 3-yr survival rate of two groups were compared. Results After treatment,interferon-γ（ INF-γ） levels of the two groups were significantly higher than those before treatment,and the observation group improved more obviously（ P〈0. 05）; The adverse reaction rate had no significant difference between the two groups（ P〈0. 05）; The 3-yr survival rate in two groups showed no statistical difference（ P〉0. 05）. Progress on the survival rate of the observation group was significantly higher than that in the control group,with significant difference（ P〈0. 05）. Conclusion DC-CIK biological treatment and chemotherapy for patients with gastric cancer underwent surgery can improve the level of cytokine and progression survival rate.