肺上皮样血管内皮瘤6例临床分析并文献复习

Report of 6 cases of pulmonary epithelioid hemangioend- othelioma and literature review

目的总结类似肺癌转移的多发性上皮样血管内皮瘤的诊断与治疗经验。方法回顾性分析2007-2014年我院确诊的6例多发性上皮样血管内皮瘤患者的临床资料并复习文献。结果 6例肺上皮样血管内皮瘤患者的临床表现缺乏特异性,1例行手术治疗,2例以顺铂为基础化疗,1例口服依托泊苷化疗,2例放弃治疗。随访提示患者总体预后良好。结论病理活检是诊断肺上皮样血管内皮瘤的主要手段,治疗方法目前主要采用以外科和化疗为主的综合治疗。

Objective To summarize the experiences in the diagnosis and treatment epithelioid hemangioendothelioma （EHE）, which is similar to lung cancer metastasis. Methods of multiple The clinical and pathological characteristics of 6 cases of pulmonary epithelioid hemangioendothelioma （PEH） were retrospectively analyzed, and the related articles were reviewed. Results Because of lacking of specific clinical manifestations, 6 cases of PEH were initially misdiagnosed as lung cancer, in which 1 case received surgery, 2 cases received cisplatin-based chemotherapy, 1 case was treated by oral administration of etoposide, and 2 cases gave up. The follow-up suggested that the patients had good prognosis overall. Conclusion PEH is easily misdiagnosed as lung cancer, and correct diagnosis and differential diagnosis about PEH require combination of imaging studies, histological observation, immunohistochemical analysis of specimens, and other methods. Combined therapy of surgery and chemotherapy is the main treatment manner, but the efficacy needs to be confirmed with more evidence-based clinical studies.