苯骈呋喃类衍生物的合成及促骨形成作用

Synthesis of benzofuran derivatives and their effect on promoting bone formation

目的设计并合成苯骈呋喃类衍生物,并研究其促骨形成作用。方法以苯甲醚为原料,经7步反应得到目标产物,并研究目标产物的促骨形成作用。结果目标化合物的结构经1HNMR、MS确证。结论目标化合物Ⅱa具有较好的促骨形成作用。

OBJECTIVE To design and synthesize benzofuran derivatives and to evaluate their effect on promoting bone formation. METHODS The target compounds were synthesized via seven steps using anisole as the starting material, and the promotion test of bone formation had been carried. RESULTS The target compounds were obtained, and the chemical structures were confirmed by 1HNMR and MS. CONCLUSION Target compound Ⅱa was effective on promoting the bone formation.