同型半胱氨酸、叶酸、维生素B12与不良妊娠的相关性研究被引量：15

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摘要目的探讨妇女血浆中同型半胱氨酸(Hcy)、叶酸(FA)及维生素B12(Vit B_(12))与不良妊娠的关系。方法收集不良妊娠结局孕妇601例,正常妊娠孕妇1141例,对照收集同期健康体检的育龄未孕妇女771例,测定其血浆Hcy、FA及Vit B_(12)水平,Hcy的检测采用化学发光法,FA和Vit B_(12)的检测采用时间分辨免疫荧光法。结果正常妊娠妇女Hcy、FA、Vit B_(12)水平均显著低于未孕对照组(P<0.05);不良妊娠妇女Hcy水平显著高于正常妊娠组(P<0.001);而不良妊娠组FA、Vit B_(12)水平均显著低于正常妊娠组(P<0.05);多元Logistic回归分析发现Hcy、年龄的升高以及Vit B_(12)水平的降低均对不良妊娠有重要的影响。结论 Hcy升高、年龄增大、Vit B_(12)缺乏均为不良妊娠发生的危险因素;Hcy、FA与Vit B_(12)的测定可以作为围孕期保健、预防不良妊娠的检测指标。

作者王瑾蔡艳曹鲁泉罗颖金华赵燕

机构地区山东省济南市妇幼保健院产前诊断中心

出处《中国妇幼保健》 CAS 2015年第35期6203-6204,共2页 Maternal and Child Health Care of China

基金山东省济南市科学技术发展计划项目〔200905051〕

关键词同型半胱氨酸叶酸 VIT B12 不良妊娠

分类号 R714.2 [医药卫生—妇产科学]

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