维生素D对儿童骨骼外系统的作用

Effects of vitamin D on childhood extraskeletal systems

维生素D除了经典的维持骨骼健康的作用外,还对骨骼外系统发挥重要作用。近年来的研究显示,儿童时期的25羟维生素D水平和脑发育、免疫功能、肥胖、代谢综合征、胰岛素抵抗、感染性疾病、过敏、肿瘤以及心血管疾病等有密切关联,而且这方面的研究已经使人们对维生素D缺乏的定义以及维生素D最佳营养状况的认识发生了改变。鉴于维生素D在儿童健康方面的重要作用,更多的户外活动和维生素D补充是必要的。

Vitamin D may play an important role in extraskeletal system beyond its traditional effect on the skeleton. Emerging evidence supports an association between 25-hydroxyvitamin D3（25 [ OH ] D3） levels and brain development, immune function, obesity, metabolic syndrome, insulin resistance, infection, allergy, cancers, and caidiovascular diseases in pediatric and adolescent populations. Mary studies have influenced the definition of vi- tamin D deficiency and what level of vitamin D should be regarded as optimal. Given the important role of vitamin D in childhood health, more time spent in outdoor activity and vitamin D sup-plementation may be necessary for optimal health in infants, children, and adolescents.