成人哮喘血清维生素D水平与肺功能相关因素分析

Correlation of serum vitamin D level with pulmonary function related factors in adult asthma

目的探讨成人哮喘患者血清维生素D(VitD)与肺功能的相关性。方法支气管哮喘患者(哮喘组)62例,其中轻、中及重度组分别为6、13及43例;同期健康体检者(对照组)28例。酶联免疫吸附法测定血清25-羟维生素D[25(OH)D]浓度。用肺功能仪检测支气管哮喘患者用力肺活量(FVC)、第1秒最大呼气量(FEV_1),计算第1秒用力呼气容积占预计值百分比(FEV_1%pred)、第1秒最大呼气率(FEV_1/FVC%)。观察哮喘组不同性别及各亚组轻、中及重度组的病史、年龄、身高等一般情况差异及VitD水平。分析哮喘组和对照组血清25(OH)D含量差异,哮喘组和其3个亚组血清25(OH)D含量与FEV_1%pred的相关性。结果哮喘组不同性别和轻、中、重度组间年龄、身高及体质量等差异均无统计学意义,男性病程长于女性(P<0.05)。哮喘组血清25(OH)D[(29.69±20.45)]nmol/L低于对照组[(75.16±4.06)]nmol/L(P<0.05);重度组血清25(OH)D低于轻、中度组(P<0.05);哮喘组及其3个亚组25(OH)D与FEV_1%pred均呈正相关(P<0.05)。结论支气管哮喘患者普遍存在VitD缺乏现象,成人支气管哮喘患者的血清25(OH)D低水平与其严重性有关,与其肺功能呈正相关。

Objectives To explore the correlation of level of serum 25-hydroxyvitamin D with pulmonary function in adult with asthma. Methods Patients were divided into Asthmatic group（n=62）and Control group （n=28）. The Asthmatic group was further divided into Mild Group （n=6）, Moderate Group （n=13） and Severe Group （n=43）. Serum levels of 25-hydroxyvitamin D [25（OH）D], denoted as ＂25（OH） Vit D＂ was detected by ELISA. Pulmonary function indicators,including FVC （forced vital capacity） , FEV1 （forced expiratory volume in 1 second） , FEV1%predicted , and FEV1/FVC%were determined by a pulmonary function testing device. General profiles such as medical history, age and height as well as serum VitD levels were compared between subgroups of the asthmatic groups and between two genders. Serum levels of 25 （OH） VitD were compared between asthmatic group and control group while its correlation with FEV1%predicted were calculated in all three sub asthmatic groups. Results There was no significant difference in medical history, age, height and the 25（OH） VitD levels between male and female participants. Serum 25（OH） Vit D level was significantly lower in the asthmatic patient group [（29.69±20.45） nmol/L] compared to that in control group [（75.16±4.06） nmol/L] （P〈0.05）. It was significantly lower in severe sub group than those in the mild and moderate sub groups. The differences were both statistically significant （ P〈0.05）. There were positive correlations between serum 25（OH） Vit D levels and FEV1%predicted （ P〈0.05） in all sub asthmatic groups. Conclusion Vitamin D deficiency is highly prevalent in asthmatic patients, and there is a strong correlation between 25（OH） Vit D asthma severity as well as between lung function.0.05）. There were positive correlations between serum 25（OH） Vit D levels and FEV1% predicted （ P 〈 0.05） in all sub asthmatic groups. Conclusion Vitamin D deficiency is highly prevalent in asthmatic patients, and there is a strong correlation between 25（OH） Vit D asthma severity as well as between lung function.